Table 1.
Descriptive Characteristic of the Participants Included in the Study
| LB+NL+ (N = 17) | LB−NL+ (N = 17) |
LB−NL− (N = 17) | |
|---|---|---|---|
|
| |||
| demographic | |||
| age at death, (years) | 87.7 ± 3.0 | 88.5 ± 4.1 | 87.8 ± 3.1 |
| female sex (n, %) | 10 (59%) | 10 (59%) | 10 (59%) |
| education, (years) | 16.1 ± 3.3 | 15.1 ± 3.3 | 15.2 ± 3.2 |
| postmortem interval (h) | 7.3 ± 1.6 | 6.2 ± 1.8 | 5.7 ± 1.3 |
| APOE e4 allele (n, %) | 6 (35%) | 5 (29%) | 3 (18%) |
| MMSE | 18.8 ± 9.0 | 20.1 ± 10.1 | 24.1 ± 9.4 |
| global parkinsonism, max 100 | |||
| Parkinsonian gait | 46.2 ± 19.3 | 42.9 ± 19.3 | 30.2 ± 19.2 |
| rigidity | 9.1 ± 12.3 | 13.8 ± 21.4 | 7.9 ± 11.7 |
| tremor | 4.1 ± 5.5 | 5.5 ± 13.7 | 3.2 ± 8.7 |
| bradykinesia | 18.2 ± 14.1 | 25.5 ± 18.7 | 12.4 ± 17.3 |
| pathological (n, %) | |||
| PD pathological diagnosis | 6 (35%) | 0 (0%) | 0 (0%) |
| AD pathological diagnosis | 14 (82%) | 11 (65%) | 9 (53%) |
| macroscopic infarcts | 5 (29%) | 6 (35%) | 6 (35%) |
| microinfarcts | 4 (24%) | 6 (35%) | 5 (29%) |
| Lewy bodies positive | 17 (100%) | 0 (0%) | 0 (0%) |
| hippocampal sclerosis |
4 (24%) | 1 (6%) | 2 (12%) |
| TDP-43 inclusion positive | 11 (65%) | 9 (56%) | 9 (60%) |
| cerebral amyloid angiopathy positive | 15 (88%) | 16 (94%) | 14 (82%) |
| atherosclerosis | 13 (76%) | 15 (88%) | 14 (82%) |
| arteriolar sclerosis | 16 (94%) | 15 (88%) | 13 (76%) |
| loss of pigmented neurons in SN | 16 (94%) | 16 (94%) | 1 (6%) |
| β-amyloid load (score) | 6.0 ± 3.7 | 3.5 ± 2.6 | 2.8 ± 2.7 |
| PHFtau tangle density (score) | 9.3 ± 7.7 | 9.8 ± 18.7 | 8.1 ± 10.5 |