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. 2022 Jun 13;109:108903. doi: 10.1016/j.intimp.2022.108903

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Fig. 2 — Metformin prevented long-term isoflurane exposure induced microglia activation in the hippocampus. (A, B and C) Representative immunofluorescent images of the IBA1 positive microglia (red) expressing CD68 (green) in the hippocampal CA1 (A), CA3 (B), and DG (C) regions of adult mice receiving vehicle (Ctrl), isoflurane (Anes), metformin (Met) or metformin and isoflurane (Met + Anes). Scale bar = 50 μm. (D, E) The quantification of the percentage of IBA1 positive area in the total area of the image (D) and CD68 positive area in IBA1 + microglia (E) in each hippocampal region, (n = 3 mice per group). Data are expressed as mean ± SD and analyzed with one-way ANOVA test followed by Bonferroni multiple comparison test. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)