Table 2.
Muscle phenotypic features before and after PRT
| Baseline |
Percent Change after PRT |
|||||
|---|---|---|---|---|---|---|
| Cellular Muscle Features | Mean, SD/Median | Range Min-Max | n (Female) | Mean (SD)/Median | Range Min-Max | n (Female) |
| Mean fCSA | 3,951.5 (1,548.6)/3,592.8 | 2,079.1–8,471.9 | 38 (23) | 13.1 (30.1)/10.3$ | −38.4 to −91.6 | 32 (19) |
| T1 fCSA | 4,564.2 (1,610.0)/4,196.2 | 2,302.9–8,337.1 | 38 (23) | 8.6 (30.8)/2.6 | −39.7 to −85.1 | 32 (19) |
| T2 fCSA | 3,512.7 (1,758.4)/2,873.7 | 1,541.0–8,977.5 | 38 (23) | 19.6 (30.8)/14.0* | −28.4 to –100.9 | 32 (19) |
| T1 FF,% | 44.3 (17.0)/42.7 | 5.8–90.8 | 38 (23) | −10.1 (25.0)/−14.2* | −60.4 to −58.9 | 32 (19) |
| T2a FF,% | 26.6 (13.2)/26.6 | 1.0–59.7 | 38 (23) | 71.3 (82.2)/51.2* | −36.4 to –292.2 | 32 (19) |
| T2a/x FF,% | 27.6 (19.1)/26.7 | 0.0–91.3 | 38 (23) | −12.0 (76.4)/−25.2* | −97.1 to –315.1 | 32 (19) |
| CD11b+/CD206− cells/fiber | 0.04 (0.03)/0.03 | 0.01–0.14 | 37 (20) | 92.4 (140.4)/34.5 | −77.5 to –438.8 | 32 (19) |
| CD11b+/CD206+ macs/fiber | 0.2 (0.1)/0.1 | 0.05–0.75 | 37 (20) | 64.2 (84.1)/39.3* | −60.3 to –331.0 | 32 (19) |
| % CD11b+/CD206− cells/total | 17.2 (7.3)/17.2 | 7.0–38.8 | 37 (20) | 13.9 (57.6)/−4.6* | −66.1 to –163.8 | 32 (19) |
| % CD11b+/CD206+ macs/total | 82.8 (7.3)/82.8 | 61.2–93.0 | 37 (20) | 0.8 (9.3)/2.1 | −16.7 to −23.3 | 32 (19) |
| Total CD11b+ cells/fiber | 20.8 (14.4)/17.8 | 5.6–89.2 | 37 (20) | 63.6 (82.1)/48.2* | −63.0 to –309.9 | 32 (19) |
| T1 SC/fiber | 0.09 (0.04)/0.08 | 0.05–0.18 | 32 (20) | 17.5 (47.1)/14.5 | −57.0 to –97.2 | 32 (20) |
| T2 SC/fiber | 0.06 (0.03)/0.05 | 0.01–0.14 | 32 (20) | 34.1 (77.0)/13.2$ | −77.8 to –237.8 | 32 (20) |
| Mean SC/fiber | 0.08 (0.03)/0.08 | 0.03–0.13 | 32 (20) | 25.8 (55.7)/19.7$ | −64.9 to –154.6 | 32 (20) |
| All MN/fiber | 1.9 (0.7)/1.8 | 0.8–3.9 | 30 (17) | 6.0 (31.1)/5.2 | −43.4 to –92.2 | 30 (17) |
| T1 MN/fiber | 2.1 (0.8)/2.0 | 0.8–3.9 | 29 (16) | 4.7 (34.8)/−1.1 | −49.0 to –82.9 | 29 (16) |
| T2 MN/fiber | 1.8 (0.8)/1.6 | 0.8–4.0 | 29 (16) | 1.4 (31.2)/−6.7 | −50.2 to –94.0 | 29 (16) |
| Total collagen content, % SR+ | 6.9 (2.6)/6.7 | 2.3–13.7 | 31 (16) | 1.9 (61.4)/−9.7 | −72.7 to –262.7 | 31 (16) |
| Loose CO, Green per area | 318.7 (47.7)/303.9 | 139.4–382.3 | 33 (17) | −1.2 (13.5)/−2.0 | −19.4 to –58.4 | 33 (17) |
| Dense CO, Red per area | 508.3 (91.1)/508.7 | 205.0–835.9 | 33 (17) | 0.3 (17.4)/−1.7 | −38.6 to –62.1 | 33 (17) |
| Capillaries/Fiber | 1.2 (0.4)/1.2 | 0.6–2.1 | 33 (17) | 16.5 (30.3)/14.0* | −44.0 to –80.4 | 33 (17) |
| DXA bilateral thigh muscle mass normalized, kg/cm | 232.0 (43.7)/221.3 | 160.7–329.2 | 48 (29) | 3.8 (5.8)/5.0 | −10.4 to –16.5 | 48 (29) |
| CT thigh muscle (−29 to 150 HU) area, cm2 | 111.2 (25.1)/105.1 | 69.4–159.6 | 48 (29) | 5.7 (6.2)/5.1 | −14.9 to –23.3 | 44 (28) |
CO, collagen organization; CT, computed tomography; DXA, dual-energy X-ray absorptiometry; fCSA, fiber cross-sectional area; FF, fiber frequency; macs, macrophages; MN, myonuclei; PRT, progressive resistance training; SC, satellite cells; SD, standard deviation; SR, Sirius Red; T, type.
*
Significant pre/postdifference; $trend (P value = 0.051–0.12).