FIGURE 3.

Hyperactivation of innate immune responses during pregnancies with complications During pregnancy, increased circulating pathogen-associated molecular patterns (PAMPs) due to bacterial infections or danger-associated molecular patterns (DAMPs; e.g., mitochondrial DNA) due to placental or maternal organ damage and cell death can cause hyperactivation of innate immune mechanisms resulting in pathogenic systemic inflammation that can be detrimental to both mother and fetus, inducing adverse pregnancy outcomes (e.g., preeclampsia). Image created with BioRender.com and used with permission.