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. Author manuscript; available in PMC: 2022 Jun 13.
Published in final edited form as: Exp Eye Res. 2021 Jan 28;205:108444. doi: 10.1016/j.exer.2021.108444

Fig. 1. Graphical illustration of nano-enhanced optical delivery.

Fig. 1.

(A) Two-step surface functionalization of GNR using specific antibody to targeted retina binding. (B) Scanning electron microscope image of functionalized gold nanorods, (C) zoomed picture showing individual nanorods. (D) Schematics of targeted binding of antibody functionalized gold nanorods to specific retinal layers and expression of opsin (and mCherry reporter) upon light irradiation due to fGNR-based enhancement of light intensity in the vicinity of targeted cells. ONL: Outer Nuclear Layer; INL: Inner Nuclear layer; and GCL: Ganglion Cell Layer.