Fig. 2.
Melatonin diminishes brain inflammation. A-G mRNA levels of Tnf, Il1b, Il6, Cxcl1, Cxcl2, Trem1, Ms4a8a in the cortex of SARS-CoV-2-infected mice at sacrifice day 7 were determined by RT-qPCR (n = 6). *p < 0.05, **p < 0.01, ****p < 0.0001, by Kruskal–Wallis test with two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli as post test for multiple comparisons. H-N Contingency distribution of infected mice in different treatment categories depending on tercentile classification of inflammatory markers. p values of χ2 test between vehicle and MLT50 treatment considering “Low” and “High” levels of inflammatory markers are indicated (*p < 0.05)