Fig. 4.

Effect of melatonin on the expression of components involved in cell entry of SARS-CoV-2 in the brain. A Detection in mouse brain of melatonin receptor transcripts, Mtnr1a (white) and Mtnr1b (red), in the cortical vasculature (positive for collagen IV). B–I mRNA levels of Pecam (CD31, endothelial marker), Elavl4 (HuD, neuronal marker), Nrp1, mouse Ace2, human ACE2, Tmprss2, Nfkb1 and RelA in sorted cortical cells positive or negative for CD31 from non-infected K18-hACE2 mice (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 by One-way ANOVA with post hoc Tukey test for correction of multiple comparison