TABLE 2.

HCC Staging Definitions

Stage	Description	Code
Single lesion in 1 lobe	Single lesion (1 lobe)	EOD extension: 10 CS extension: 100
Multiple tumors or >1 lobe involved	Multiple (satellite) tumors/nodules (1 lobe) without intrahepatic vascular invasion, including NOS; confined to liver, NOS; localized, NOS	EOD extension: 30, or 50 CS extension: 150, 170, 250, 270, and 390
Vascular invasion	Lesion(s) with intrahepatic vascular invasion or extension to extrahepatic blood vessel(s)	EOD extension: 20, 40, 60, 61, 62, 65, 70, 75, and 80 CS extension: 350, 370, 380, 400, 420, 440, 460, 600, 630, 635, 638, 639, 640, 645, 660, 700, 750, 755, 770, 800, and 810
Metastatic disease	Metastasis or distant lymph node involvement	EOD extension: 85 or EOD lymph node involvement: 6 or 7 CS metastases at diagnosis: 10–60 or CS lymph nodes: 200–800

Abbreviations: CS, collaborative stage; EOD, extent of disease, HCC, hepatocellular carcinoma; NOS, not otherwise specified.