TABLE 3.
Demographic, Clinicopathologic, and Treatment Characteristics by Sex in Patients With HCC: SEER Data 1988 Through 2010
| Characteristics | Total (N=39,345) | Men (N=29,788; 76%) | Women (N=9557; 24%) | P a |
|---|---|---|---|---|
|
| ||||
| Median age (range), y | 62 (18–89) | 61 (18–89) | 67 (18–89) | <.001 |
| Age group, y | ||||
| 18–44 | 1888 (5%) | 1455 (5%) | 433 (5%) | |
| 45–54 | 8168 (21%) | 6848 (23%) | 1320 (14%) | |
| 55–64 | 11,941 (30%) | 9656 (32%) | 2285 (24%) | <.001 |
| 65–74 | 9902 (25%) | 7064 (24%) | 2838 (30%) | |
| ≥75 | 7446 (19%) | 4765 (16%) | 2681 (28%) | |
| Race | ||||
| White | 19,586 (50%) | 15,067 (51%) | 4519 (47%) | |
| African American | 4826 (12%) | 3696 (12%) | 1130 (12%) | |
| Asian | 8293 (21%) | 6015 (20%) | 2278 (24%) | <.001 |
| Hispanic | 6236 (16%) | 4719 (16%) | 1517 (16%) | |
| Native American | 404 (1%) | 291 (1%) | 113 (1%) | |
| Stage | ||||
| Liver-limited disease | ||||
| Single lesion in one lobe | 10,780 (27%) | 7762 (26%) | 3018 (32%) | |
| Tumor size, cm | ||||
| <3 | 3151 (29%) | 2249 (29%) | 902 (30%) | .78b |
| 3–5 | 3021 (28%) | 2178 (28%) | 843 (28%) | |
| ≥5 | 3682 (34%) | 2660 (34%) | 1022 (34%) | |
| Unknown | 926 (9%) | 675 (9%) | 251 (8%) | |
| Multiple tumors/multilobar disease | 8037 (20%) | 6104 (20%) | 1933 (20%) | <.001c |
| Vascular invasion | 14,297 (36%) | 11,007 (37%) | 3290 (34%) | |
| Metastatic disease | 6231 (16%) | 4915 (16%) | 1316 (14%) | |
| Treatmentd | ||||
| None or unknown | 24,225 (70%) | 18,633 (71%) | 5592 (68%) | |
| Liver-directed therapy | 3921 (11%) | 2969 (11%) | 952 (12%) | |
| Surgical resection | 3960 (11%) | 2782 (11%) | 1178 (14%) | <.001 |
| Liver transplantation | 2568 (7%) | 2029 (8%) | 539 (7%) | |
Abbreviations: HCC, hepatocellular carcinoma; SEER, Surveillance, Epidemiology, and End Results.
a
Based on Wilcoxon or chi-square test whenever appropriate.
b
For comparison of tumor size between men and women among subjects with a single lesion in 1 lobe.
c
For comparison of liver-limited disease (including a single lesion in 1 lobe, multiple tumors/multilobar disease, and vascular invasion) and metastatic disease between men and women.
d
Among patients diagnosed in 1998 or later (n=34,674).