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. Author manuscript; available in PMC: 2022 Jun 13.
Published in final edited form as: Neuropharmacology. 2020 Jan 7;167:107933. doi: 10.1016/j.neuropharm.2019.107933

FIGURE 3.

FIGURE 3.

Hallucinogen potencies in mice and rats are robustly correlated. (TOP) Hallucinogen potencies in the mouse head-twitch response (HTR) assay are correlated (r = 0.9484) with published ED50 values from rat drug discrimination studies using 0.08 mg/kg LSD as the training drug. (BOTTOM) Hallucinogen potencies in the mouse HTR assay are correlated (r = 0.9564) with published ED50 values from rat drug discrimination studies using 1 mg/kg DOM as the training drug. The drug discrimination data are taken from Tables 4 and 5, respectively. Potencies in mice and rats are plotted as log 1/ED50 (in moles/kg).