Table 1.

Summary of the head twitch response (HTR) data from dose-response experiments.

Compound	ANOVA	Time (min)	Dose (mg/kg)	N	HTR Counts (Mean ± SEM)	ED50 mg/kg (95% CI)	ED₅₀ μmol/kg (95% CI)
DOM^a	F(5,23)=17.1, p<0.0001	30	0	5	4.6 ± 0.9	0.43 (0.30–0.62)	1.75 (1.22–2.52)
			0.1	5	17.4 ± 1.7
			0.3	5	52.6 ± 8.0
			1	5	118.0 ± 14.5 ^**
			3	5	126.8 ± 24.4 ^**
			10	4	27.0 ± 8.6

DOET^a	F(4,22)=7.68, p=0.0005	30	0	6	7.5 ± 1.7	0.20 (0.11–0.36)	0.77 (0.43–1.37)
			0.1	5	34.8 ± 8.7
			0.3	5	86.2 ± 9.6 ^*
			1	6	122.0 ± 29.3 ^**
			3	5	71.0 ± 14.2 ^*

DOBU^c	F(4,26)=36.68, p<0.0001	30	0	7	6.6 ± 1.9	1.17 (0.99–1.38)	4.64 (3.92–5.50)
			0.3	6	13.0 ± 2.5
			1	6	46.3 ± 6.3 ^**
			3	6	111.8 ± 12.4 ^**
			10	6	25.5 ± 7.7

DOC^a	F(3,18)=23.92, p<0.0001	30	0	6	8.2 ± 1.4	0.32 (0.21–0.47)	1.19 (0.80–1.77)
			0.3	5	64.0 ± 2.0 ^**
			1	6	125.3 ± 13.5 ^**
			3	5	89.8 ± 16.3 ^**

R-(-)-DOI^a	F(4,23)=25.14, p<0.0001	30	0	7	9.4 ± 1.7	0.24 (0.17–0.33)	0.66 (0.47–0.93)
			0.1	5	27.2 ± 3.1
			0.3	6	89.2 ± 12.0 ^**
			1	5	132.0 ± 17.0 ^**
			3	5	97.0 ± 12.8 ^**

DON^a	F(4,20)=7.65, p=0.0007	30	0	5	6.4 ± 2.3	1.31 (0.70–2.43)	4.72 (2.54–8.77)
			0.3	5	17.4 ± 3.4
			1	5	43.0 ± 1.2
			3	5	102.8 ± 6.9 ^**
			10	5	96.2 ± 34.9 ^**

MDA^a	F(4,22)=3.53, p=0.0227	30	0	6	6.2 ± 1.4	1.46 (0.72–2.98)	6.77 (3.33–13.8)
			0.3	5	6.6 ± 1.2
			1	5	9.6 ± 1.1
			3	6	16.7 ± 2.4 ^*
			10	5	15.0 ± 5.1

R-(-)-MDA^a	F(4,23)=8.11, P=0.0003	30	0	6	7.8 ± 1.4	1.45 (0.82–2.54)	6.71 (3.82–11.8)
			0.3	5	8.6 ± 1.5
			1	6	15.5 ± 3.2
			3	6	30.0 ± 6.2 ^**
			10	5	27.6 ± 2.8 ^**

α-Et-2C-D^a	F(4,23)=3.95, P=0.0139	30	0	5	9.4 ± 2.6	4.09 (2.70–6.22)	15.8 (10.4–23.9)
			3	6	14.2 ± 4.1
			6	5	25.4 ± 4.9 ^*
			12	6	26.0 ± 2.2 ^*
			24	6	14.5 ± 4.0

25D-NBOMe^a	F(5,28)=10.57, P<0.0001	30	0	6	6.2 ± 0.8	0.23 (0.12–0.43)	0.64 (0.34–1.22)
			0.03	5	12.2 ± 2.9
			0.1	6	39.2 ± 7.5
			0.3	6	45.0 ± 12.5
			1	6	96.7 ± 17.2 ^**
			3	5	85.6 ± 18.9 ^**

25I-NBOH^a	F(5,24)=8.90, P<0.0001	30	0	5	4.4 ± 1.4	0.085 (0.055–0.132)	0.19 (0.12–0.29)
			0.03	5	22.8 ± 3.1
			0.1	5	48.8 ± 4.7 ^*
			0.3	5	95.6 ± 14.2 ^**
			1	5	64.0 ± 12.6 ^**
			3	5	44.4 ± 17.0

5-MeO-AMT^a	F(4,22)=10.65, p<0.0001	30	0	6	4.3 ± 0.8	0.53 (0.25–1.11)	2.21 (1.06–4.60)
			0.1	5	9.4 ± 2.8
			0.3	5	11.0 ± 3.0
			1	6	45.0 ± 11.4 ^**
			3	5	50.4 ± 7.4 ^**

DMT^b	F(4,21)=41.25, p<0.0001	30	0	6	6.5 ± 2.4	1.54 (1.08–2.19)	5.05 (3.55–7.19)
			0.3	5	11.4 ± 1.8
			1	5	25.2 ± 3.5 ^*
			3	5	65.6 ± 8.6 ^**
			10	5	76.4 ± 6.2 ^**

DET^b	F(5,25)=6.20, p=0.0007	20	0	6	3.5 ± 0.5	2.28 (1.57–3.30)	6.85 (4.72–9.93)
			0.625	5	4.0 ± 1.5
			1.25	5	4.6 ± 1.9
			2.5	5	13.0 ± 3.6 ^*
			5	5	18.8 ± 3.0 ^**
			10	5	13.0 ± 3.7 ^*

DPT^a	F(4,20)=4.02, p=0.0150	20	0	5	4.4 ± 0.5	1.90 (1.14–3.19)	6.78 (4.04–11.4)
			0.625	5	6.4 ± 1.5
			1.25	5	7.8 ± 2.7
			2.5	5	26.2 ± 7.1 ^*
			5	5	24.8 ± 9.0 ^*

DIPT^a	F(4,22)=8.9, p=0.0002	30	0	6	6.0 ± 0.4	2.40 (1.67–3.44)	8.54 (5.96–12.2)
			1.25	5	16.6 ± 4.3
			2.5	5	27.6 ± 7.1
			5	6	53.5 ± 5.3 ^**
			10	5	40.8 ± 12.0 ^**

p < 0.05

^**

p < 0.01, significant difference from the vehicle control group (Dunnett’s test).

Hydrochloride salt

fumarate salt

freebase.