Skip to main content
. 2022 Jun 13;18(6):e1010229. doi: 10.1371/journal.pgen.1010229

Fig 9. A diagram illustrating 20E regulates glycometabolism reprogramming, autophagy, and apoptosis via KLF15.

Fig 9

20E promotes the expression of Klf15 via nuclear receptors (1). By binding to the KLF bs, KLF15 promotes the transcription of Pepck, a crucial enzyme in gluconeogenesis (2). KLF15 increases the transcription of the autophagy-related gene Atg8 to induce autophagy (3), thereby providing substrates for gluconeogenesis. The increase of glucose during metamorphosis is due to trehalose and glycogen degradation, glycolysis inhibition, and gluconeogenesis (4).