Figure 5.

Erastin-induced ferroptosis reverses the antilipid peroxidation effect of treadmill training. (a–d) The effects of erastin on activities of GSH-PX and levels of GSH, MDA, and iron from different groups, respectively. Treadmill training could inhibit the lipid peroxidation induced by cerebral I/R. However, when SLC7A11 was inhibited, treadmill training inhibiting ferroptosis effects could be partially repealed. ^∗∗∗p < 0.001 vs. sham; ^∗∗∗∗p < 0.0001 vs. sham; ^#p < 0.05 vs. MCAO; ^##p < 0.05 vs. MCAO; ^&p < 0.05 vs. MCAO + Treadmill.