Table 1.
Effects of GC on antioxidant enzymes and inflammatory cytokines in PQ-induced ALI rat model.
| Group | Control | PQ | PQ + GC | ||
|---|---|---|---|---|---|
| Dose (mg/kg) | 30 | 8 | 16 | 32 | |
| GSH (μM) | 258.15 ± 27.27 | 73.65 ± 14.07## | 137.91 ± 28.80∗∗ | 168.48 ± 14.97∗∗ | 188.66 ± 21.30∗∗ |
| NADPH (μM) | 3.49 ± 0.37 | 6.57 ± 0.26## | 5.61 ± 0.23∗∗ | 4.58 ± 0.30∗∗ | 3.95 ± 0.31∗∗ |
| SOD (U/mL) | 143.60 ± 22.34 | 69.29 ± 6.23## | 95.83 ± 2.86∗∗ | 118.98 ± 2.79∗∗ | 140.04 ± 5.76∗∗ |
| CAT (U/mL) | 8.83 ± 0.58 | 3.67 ± 0.77## | 5.29 ± 0.52∗∗ | 6.50 ± 0.29∗∗ | 7.29 ± 0.31∗∗ |
| MDA (nM) | 1.71 ± 0.14 | 7.63 ± 0.78## | 5.32 ± 0.62∗∗ | 4.02 ± 0.46∗∗ | 2.52 ± 0.30∗∗ |
| LDH (U/L) | 3690.37 ± 117.49 | 10105.00 ± 792.10## | 7064.54 ± 699.47∗∗ | 6188.48 ± 506.88∗ | 3835.30 ± 544.71∗∗ |
| CK (U/mL) | 0.52 ± 0.11 | 1.81 ± 0.16## | 1.26 ± 0.12∗∗ | 0.80 ± 0.12∗∗ | 0.66 ± 0.08∗∗ |
| TNF-α (pg/mL) | 8.26 ± 0.81 | 97.95 ± 6.83## | 61.17 ± 7.05∗∗ | 39.63 ± 6.69∗∗ | 23.43 ± 4.64∗∗ |
| IL-1β (pg/mL) | 31.32 ± 5.63 | 280.55 ± 9.12## | 183.43 ± 13.40∗∗ | 79.16 ± 15.04∗∗ | 43.31 ± 10.59∗∗ |
| IL-6 (pg/mL) | 15.79 ± 2.92 | 89.95 ± 5.32## | 57.95 ± 3.64∗∗ | 39.38 ± 6.18∗∗ | 26.07 ± 2.49∗∗ |
Values were expressed as mean ± S.D. (n = 8). ##P < 0.01 vs. the control group; ∗P < 0.05, ∗∗P < 0.01 vs. the PQ group.