Table 3.
Effects of GC on antioxidant enzymes and inflammatory cytokines in PQ-induced RLE-6TN model after Nrf2 gene silencing.
| Group | Control | PQ | PQ + GC | ||
|---|---|---|---|---|---|
| Dose (μM) | 20 | 1 | 10 | 100 | |
| GSH (mg/g pro) | 2.62 ± 0.10 | 1.48 ± 0.37## | 1.51 ± 0.27 | 1.63 ± 0.19 | 1.54 ± 0.25 |
| NADPH (μM) | 11.75 ± 1.62 | 23.88 ± 2.08## | 24.22 ± 3.49 | 26.86 ± 2.48 | 25.23 ± 3.06 |
| SOD (U/mg pro) | 359.35 ± 24.58 | 143.99 ± 22.54## | 155.19 ± 32.02 | 150.65 ± 29.62 | 159.66 ± 23.47 |
| CAT (U/mL) | 6.08 ± 1.39 | 1.61 ± 0.25## | 1.63 ± 0.34 | 1.69 ± 0.13 | 1.49 ± 0.22 |
| MDA (nM/mg pro) | 9.05 ± 2.78 | 25.93 ± 2.73## | 25.30 ± 2.76 | 23.46 ± 1.90 | 23.78 ± 3.60 |
| LDH (U/L) | 556.27 ± 26.89 | 1129.16 ± 94.37## | 1123.00 ± 100.85 | 1100.44 ± 96.97 | 1078.73 ± 77.58 |
| CK (U/mg pro) | 0.44 ± 0.08 | 1.33 ± 0.14## | 1.15 ± 0.24 | 1.21 ± 0.12 | 1.22 ± 0.12 |
| TNF-α (pg/mL) | 4.56 ± 0.32 | 68.97 ± 5.28## | 71.56 ± 6.23 | 71.36 ± 6.39 | 66.60 ± 4.00 |
| IL-1β (pg/mL) | 119.76 ± 15.94 | 1163.34 ± 102.87## | 1177.40 ± 60.43 | 1182.55 ± 97.18 | 1150.53 ± 108.70 |
| IL-6 (pg/mL) | 23.22 ± 3.07 | 543.87 ± 31.50## | 523.05 ± 44.95 | 538.99 ± 40.40 | 518.22 ± 52.04 |
Values were expressed as mean ± S.D. (n = 8). ##P < 0.01 vs. the control group.