Figure 3.

Cellular events involved in the induction of apoptosis through activation of extrinsic and intrinsic pathways in sepsis. See the text for detailed information. Apaf: apoptosis protease activating factor-1; ATF: activating transcription factor 1 and/or 2; Bax: Bcl-2 associated x protein; ERK1/2: extracellular signal-regulated kinase 1/2; ET-1: endothelin-1; JNK: c-Jun N-terminal kinase; NF-κB: nuclear factor κB; p38-MAPK: p38-mitogen-activated protein kinase; Smac: second mitochondria-derived activator of caspases; TRADD: TNF receptor-associated death domain.