Fig. 1. Schematic depiction of examples of intra-organ fibroblast heterogeneity in humans and mice based on scRNA-seq analysis.

Examples of gene enrichment for specific fibroblast subtypes that were defined in each study are shown. Ascensión et al.⁶⁸ summarizes four individual studies. AlvFB alveolar fibroblasts, AdvFB adventitial fibroblasts, LipFB lipofibroblasts, MyoFB myofibroblasts (sub-class: fibromyocytes), F-SH Sca1-high fibroblasts, F-SL Sca1-low fibroblasts, F-Trans transitory fibroblasts, F-WntX Wnt expressing fibroblasts. The annotations of fibroblast subtypes as well as their marker genes were compiled from the respective original works. If marker genes were not explicitly stated in the original paper, they were interpreted and derived from the available data presented in the figures. No additional analysis of the raw data was performed.