Duplicates removed	44
Excluded during initial screening (e.g. press releases; news reports; not relevant drug/indication; preclinical study; reviews; case reports; not randomized trial)	166
Excluded during writing (e.g. reviews; duplicate data; small patient number; nonrandomized/phase I/II trials)	68
Cited efficacy/tolerability articles	13
Cited articles not efficacy/tolerability	34
Search Strategy: EMBASE, MEDLINE and PubMed from 1946 to present. Clinical trial registries/databases and websites were also searched for relevant data. Key words were Permixon, Serenoa repens, saw palmetto extract, LUTS, benign prostatic hyperplasia, prostatic hypertrophy. Records were limited to those in English language. Searches last updated 7 February 2022