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. 2022 Jun 13;13(6):547. doi: 10.1038/s41419-022-04983-7

Fig. 1. KDM2A gene copy number gain contributed to KDM2A mRNA upregulation in bladder cancer.

Fig. 1

A The OncoPrint tab summarizes KDM2A genomic alterations in six sample sets. Each column represents a tumor sample, red bars indicate gene amplifications, blue bars are homozygous deletions, and green squares are missense mutations (http://www.cbioportal.org/). B Further analysis of KDM2A alterations in each of the studies. C KDM2A mRNA expression was positively correlated with KDM2A gene copy number alteration (r = 0.6, P < 0.0001, linear regression). D KDM2A gene copy number gain and amplification were positively correlated with increased mRNA expression in TCGA bladder cancer cohort. E TCGA gene copy number data showed a higher ratio of gain and amplification alterations detected in high-grade bladder cancer than in low-grade samples (high-grade, 28.2%; low-grade, 4.8%). *P < 0.05; **P < 0.01; ***P < 0.001 is based on the Student’s t test. All results are from more than three independent experiments. Values are mean ± SD.