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. 2022 Jun 13;12:9771. doi: 10.1038/s41598-022-13772-3

Figure 1.

Figure 1

Long term treatment with ARBs reduce aortic vessel contractility in a NO-dependent manner. (a) Mean arterial BP of mice after long-term treatment with ARBs for 18 weeks. (b) Long term administration of four different ARBs reduces PE-induced contraction of mouse aorta. (c) Pre-treatment with the NOS inhibitor L-NAME increases PE-induced force fourfold in the controls and abolishes the ARB-induced decrease in force development. (d) Maximum force (Emax) values in the absence and presence of L-NAME of aorta from control and ARB treated mice. One experimental mouse was euthanized due to malocclusion according to standard ethics protocols. (vehicle n = 7, losartan n = 6, olmesartan n = 7, telmisartan n = 7, valsartan n = 7).