Figure 8.

Effect of telmisartan on eNOS-dependent gene signature changes by RNA-seq. (a) Principle component analysis (PCA) of the transcripts detected in aortic tissues isolated from WT and eNOS KO mice. (b) Expression clustering of samples and regions significantly different between untreated and treated WTs but not significantly different between untreated and treated eNOS KO mice. (c) Top 20 gene ontology (GO) terms with the number of associated DEGs related to eNOS-dependent pathways regulated by telmisartan in the mouse aorta. (WT n = 2, WT + telmisartan n = 2, eNOS KO n = 4, eNOS KO + telmisartan n = 4). (d) Mechanistic overview of how ARBs/telmisartan act on eNOS and how this goes on to also have protective effects on vascular remodeling.