Table 2.
Profiles of the 32 genes identified through literature-based analysis and used to construct the significant signaling networks.
| Gene name | Description | Centrality with functional classes | Centrality with cell processes | ||
|---|---|---|---|---|---|
| Betweenness | Degree | Betweenness | Degree | ||
| IL6 | Interleukin 6 | 0.32786356 | 60 | 0.2606371 | 53 |
| MMP9 | Matrix metallopeptidase 9 | 0.14008759 | 43 | 0.08874194 | 42 |
| PRKCA | Protein kinase C alpha | 0.10249921 | 23 | 0.06604883 | 26 |
| SERPINE1 | Serpin family E member 1 | 0.0940557 | 31 | 0.03619284 | 29 |
| JUN | Jun proto-oncogene, AP-1 transcription factor subunit | 0.07616875 | 34 | 0.05170048 | 31 |
| PLAU | Plasminogen activator, urokinase | 0.0535497 | 33 | 0.03590776 | 31 |
| MMP1 | Matrix metallopeptidase 1 | 0.04540664 | 18 | 0.06081282 | 24 |
| EGR1 | Early growth response 1 | 0.02858809 | 23 | 0.01102559 | 27 |
| BIRC3 | Baculoviral IAP repeat containing 3 | 0.01057176 | 4 | 0.04105898 | 6 |
| NDRG1 | N-myc downstream regulated 1 | 0.01028651 | 3 | 0.00756754 | 11 |
| AKAP13 | A-kinase anchoring protein 13 | 0.00621003 | 4 | 0.00486438 | 3 |
| S100A8 | S100 calcium binding protein A8 | 0.00602783 | 19 | 0.01403312 | 23 |
| IGFBP3 | Insulin like growth factor binding protein 3 | 0.00470338 | 12 | 0.00350003 | 14 |
| S100A9 | S100 calcium binding protein A9 | 0.00295347 | 13 | 0.01168803 | 18 |
| ABCA1 | ATP binding cassette subfamily A member 1 | 0.00271365 | 7 | 4.68E−04 | 6 |
| SOX9 | SRY-box 9 | 0.00195307 | 9 | 0.00333093 | 13 |
| CXCL1 | C-X-C motif chemokine ligand 1 | 0.00167127 | 8 | 0.01085271 | 17 |
| ANGPTL4 | Angiopoietin like 4 | 7.66E−04 | 3 | 3.80E−04 | 6 |
| SH3KBP1 | SH3 domain containing kinase binding protein 1 | 3.22E−04 | 2 | 0 | 1 |
| STK4 | Serine/threonine kinase 4 | 3.22E−04 | 2 | 7.43E−04 | 5 |
| MAP3K20 | Mitogen-activated protein kinase kinase kinase 20 | 2.42E−04 | 2 | 2.83E−04 | 2 |
| GBP1 | Guanylate binding protein 1 | 2.25E−04 | 2 | 0 | 1 |
| THBS2 | Thrombospondin 2 | 1.93E−04 | 6 | 4.16E−04 | 7 |
| AKAP12 | A-kinase anchoring protein 12 | 0 | 2 | 0 | 3 |
| CFB | Complement factor B | 0 | 2 | 0 | 1 |
| GREM1 | Gremlin 1, DAN family BMP antagonist | 0 | 1 | 0.00179531 | 7 |
| IFI16 | Interferon gamma inducible protein 16 | 0 | 2 | 0.00127899 | 5 |
| ITGA2 | Integrin subunit alpha 2 | 0 | 3 | 2.46E−04 | 4 |
| MT1F | Metallothionein 1F | 0 | 1 | 0 | 2 |
| MYH10 | Myosin heavy chain 10 | 0 | 1 | 0 | 2 |
| SERPINB2 | Serpin family B member 2 | 0 | 4 | 1.47E−04 | 7 |
| TFPI | Tissue factor pathway inhibitor | 0 | 2 | 3.20E−04 | 6 |