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. 2022 Jun 13;12:9813. doi: 10.1038/s41598-022-13698-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathological findings of the effects of Scrophularia striata ethanolic extract on pancreas tissues of studied groups. 28 days after the experiment, pancreas tissues samples were evaluated Harris-Eosin hematoxylin staining (A) Sham, (B) Control, (C) Experimental healthy (healthy + Scrophularia striata 400 mg/kg), (D) Pre-treatment (treated before and after STZ injection with S. striata 400 mg/kg), (E) Treatment (diabetic + S. striata 400 mg/kg). No histopathological changes were observed in pancreas tissues with sham (A) and experimental healthy (C) islets of Langerhans (arrows) and ascites is seen in a normal pattern. In the control group (B) degeneration in the cells of the islets of Langerhans (arrows), and atrophy and fibrosis in the structure of the pancreas is shown. In the pre-treatment group (D) normal condition of the ascites is shown. All these lesions were markedly attenuated in S. striata treatment (400 mg/kg) (E) (H&E *200).