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. 2022 Jun 13;12:9740. doi: 10.1038/s41598-022-13888-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of luseogliflozin on the expression of key genes in the pancreatic islets of 10-week-old db/db mice. Gene expression of Slc2a2, Pcx, Cs, Aco2, Idh2, Ogdh, Sdha, and Mdh2 in the control and luseo groups, measured using real-time PCR (n = 4). The data were normalized to Gapdh expression. Values are mean ± SD. P values were determined using Student’s t test. *P < 0.05; **P < 0.01. The figure was created by Microsoft PowerPoint® 2016 (https://www.microsoft.com/microsoft-365/powerpoint). Slc2a2, solute carrier family 2 member 2; Pcx, pyruvate carboxylase; Cs, citrate synthase; Aco2, aconitase 2; Idh2, isocitrate dehydrogenase 2; Ogdh, oxoglutarate dehydrogenase; Sdha, succinate dehydrogenase complex flavoprotein subunit a; Mdh2, malate dehydrogenase 2, Gapdh, glyceraldehyde 3-phosphate dehydrogenase.