Figure 3.

Effects of luseogliflozin on the mitochondrial respiratory capacity and mitochondrial ROS generation of the pancreatic islets of 10-week-old db/db mice. (A) Mitochondrial respiratory capacity during each state in pancreatic islets from the control and luseo groups (n = 7). (B) Respiratory control ratio with each complex substrate in pancreatic islets from the control and luseo groups (n = 7). (C) Mitochondrial H₂O₂ generation during each state in pancreatic islets from the control and luseo groups (n = 7). Values are mean ± SD. P values were determined using Student’s t test. *P < 0.05; **P < 0.01. CI, complex I-linked substrates; CI + II, complex I + II-linked substrates; CII, complex II-linked substrates; L, leak state; P, oxidative phosphorylation.