Table 2.
Up- and downregulated pathways in the luseogliflozin-treated group.
| Changed genes | Total genes | Z-score | P-value | Gene symbol | |
|---|---|---|---|---|---|
| Upregulated pathways | |||||
| Fatty acid biosynthesis WP336_71737 | 2 | 22 | 4.91 | 0.01 | Pcx, Hadh |
| IL7 signaling pathway WP297_69128 | 2 | 44 | 3.20 | 0.04 | Ccna2, Ccnd2 |
| Tryptophan metabolism WP79_73389 | 2 | 44 | 3.20 | 0.04 | Hadh, Maob |
| Glycolysis and gluconeogenesis WP157_69361 | 2 | 47 | 3.06 | 0.04 | Pcx, Slc2a2 |
| Downregulated pathways | |||||
| Dopaminergic neurogenesis WP1498_60839 | 3 | 29 | 3.72 | 0.01 | Aldh1a1, Shh, Th |
| Endochondral ossification WP1270_72216 | 4 | 62 | 3.01 | 0.02 | Enpp1, Ctsl, Adamts5, Plat |
| Glucocorticoid and mineralocorticoid metabolism WP495_71740 | 2 | 13 | 3.93 | 0.02 | Hsd11b1, Cyp17a1 |
| Retinol metabolism WP1259_71742 | 3 | 38 | 3.06 | 0.03 | Aldh1a, Cd36, Bcmo1 |
| Biogenic amine synthesis WP522_69135 | 2 | 15 | 3.59 | 0.03 | Ache, Th |
| Blood clotting cascade WP460_71727 | 2 | 20 | 2.97 | 0.04 | Vwf, Plat |
P values were determined using two-tailed Fisher’s exact tests.