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. 2022 Jun 13;12:9782. doi: 10.1038/s41598-022-13067-7

Table 2.

Predictors of remission and relapse.

Remission (n = 108) Relapse after remission (n = 97)
Unadjusted
HR (95% CI)
Adjusted
HR (95% CI)
Unadjusted
HR (95% CI)
Adjusted
HR (95% CI)

Age,

18–39 years

1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference)
40–64 0.98 (0.62, 1.53) 1.39 (0.83, 2.32) 0.75 (0.38, 1.49) 0.90 (0.40, 2.04)
65–81 0.54 (0.33, 0.89)* 0.73 (0.40, 1.33) 0.82 (0.35, 1.93) 1.21 (0.44, 3.39)
Men 1.16 (0.78, 1.73) 1.42 (0.89, 2.29) 0.77 (0.42, 1.43) 0.88 (0.44, 1.76)
Body mass index, per 1.0 kg/m2 0.96 (0.92, 1.01) 0.95 (0.89, 1.01) 1.00 (0.92, 1.09) 1.04 (0.93, 1.16)
Systolic blood pressure, per 10 mmHg 0.89 (0.80, 0.99)* 1.00 (0.85, 1.17) 0.88 (0.70, 1.10) 0.87 (0.64, 1.18)
Serum albumin, per 1.0 g/dL 0.65 (0.44, 0.95)* 0.57 (0.37, 0.87)* 0.73 (0.43, 1.23) 0.93 (0.52, 1.66)
eGFR, per 30 mL/min/1.73 m2 1.33 (1.10, 1.62)* 1.43 (1.08, 1.90)* 0.93 (0.65, 1.32) 0.91 (0.58, 1.44)
UP, per 1.0 log g/day or log g/gCr 1.07 (0.76, 1.52) 1.25 (0.79, 2.00) 1.30 (0.72, 2.33) 1.05 (0.99, 1.13)

Dipstick hematuria,

 − or ± 

1.00 (reference) 1.00 (reference) 1.00 (reference) 1.00 (reference)
 1+  0.86 (0.50, 1.47) 1.31 (0.71, 2.41) 0.82 (0.34, 1.96) 0.64 (0.24, 1.70)
 ≥ 2+ 0.72 (0.47, 1.10) 0.92 (0.55, 1.53) 1.40 (0.72, 2.72) 1.57 (0.69, 3.55)
Intravenous albumin administration 0.67 (0.37, 1.23) 0.97 (0.44, 2.15) 0.47 (0.11, 1.96) 0.15 (0.02, 1.25)
Intravenous mPSL within 1 month of IST 0.66 (0.42, 1.03) 0.68 (0.41, 1.11) 0.96 (0.47, 1.94) 0.86 (0.40, 1.85)
Cyclosporine within 1 month of IST 0.58 (0.31, 1.09) 0.65 (0.32, 1.33) 0.64 (0.23, 1.80) 0.87 (0.28, 2.65)

CI confidence interval, eGFR estimated glomerular filtration rate, HR hazard ratio, mPSL methylprednisolone, UP urinary protein.

*P < 0.05.

Including 97 patients with remission of proteinuria within 6 months of IST.

Adjusted for all variables listed in the table.