Table 3.
Serum albumin, eGFR, and the incidence of remission.
| Category | N | Remission N (%) |
Unadjusted HR (95% CI) |
Adjusted HR (95% CI)† |
|---|---|---|---|---|
| Serum albumin | ||||
| ≤ 1.00 g/dL | 12 | 12 (100.0) | 2.18 (1.07, 4.46)* | 2.47 (1.14, 5.34)* |
| 1.01–1.50 | 41 | 40 (97.6) | 1.79 (1.06, 3.01)* | 2.32 (1.31, 4.14)* |
| 1.51–2.00 | 28 | 28 (100.0) | 1.27 (0.73, 2.20) | 1.51 (0.83, 2.73) |
| > 2.00 | 27 | 24 (88.9) | 1.00 (reference) | 1.00 (reference) |
| eGFR | ||||
| < 30.0 mL/min/1.73 m2 | 11 | 10 (90.9) | 1.00 (reference) | 1.00 (reference) |
| 30.0–59.9 | 28 | 28 (100.0) | 1.69 (0.81, 3.52) | 1.21 (0.54, 2.70) |
| 60.0–89.9 | 48 | 46 (95.8) | 2.90 (1.45, 5.81)* | 2.59 (1.18, 5.70) |
| ≥ 90.0 | 21 | 20 (95.2) | 2.81 (1.30, 6.05)* | 2.73 (1.09, 6.84) |
| eGFR and serum albumin | ||||
| < 60.0 mL/min/1.73 m2 and > 1.50 g/dL | 19 | 18 (94.7) | 0.50 (0.28, 0.89)* | 0.48 (0.23, 1.00)* |
| < 60.0 and ≤ 1.50 | 20 | 20 (100.0) | 0.82 (0.47, 1.43) | 0.85 (0.45, 1.59) |
| ≥ 60.0 and > 1.50 | 36 | 34 (94.4) | 1.00 (reference) | 1.00 (reference) |
| ≥ 60.0 and ≤ 1.50 | 33 | 32 (97.0) | 1.84 (1.13, 3.02)* | 2.20 (1.28, 3.81)* |
CI confidence interval, eGFR estimated glomerular filtration rate, IRR incidence rate ratio.
*P < 0.05.
†Adjusted for age (18–40, 41–64, and ≥ 65 years), sex, body mass index (kg/m2), systolic blood pressure (mmHg), serum albumin (g/dL, if eGFR), eGFR (mL/min/1.73 m2, if serum albumin), urinary protein (log g/day or log g/gCr), dipstick hematuria (− or ± , 1+, and ≥ 2+), use of intravenous albumin before immunosuppressive therapy, and use of intravenous methylprednisolone and cyclosporine within 1 month after initiating immunosuppressive therapy.