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. 2022 Jun 13;12:9777. doi: 10.1038/s41598-022-13911-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Protein–protein interaction (PPI) networks construction for target proteins of Que against AF. (a) The chemical structure of the quercetin. (b) GEO Volcano Map. Red upregulates the target, green downregulates the target; (c) GEO Difference Chart Differential. Gene expression in normal subjects (green) vs AF patients (purple). (d) Venn diagram of Que AF and GEO. (e) PPI network of Que against AF. The larger the circle and the darker the color, the stronger the correlation with the therapeutic target.