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. 2022 Jun 13;7:185. doi: 10.1038/s41392-022-00985-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — RNF138 reduction coincided with aberrant activation of NF-кB signaling and correlated with unfavorable clinical outcomes in the CRC patients. a Correlation between log(pp65 N/C) and RNF138-staining according to Pearson’s test. The formula, coefficient of correlation (r), and the P value are indicated (n = 420). b Assessment of log(pp65 N/C) expression levels in low (n = 207) and high (n = 213) RNF138 CRC tissues. Data are mean ± SEM. Kaplan–Meier survival curves of DFS (c) and OS (d) stratified by RNF138 and pp65 N/C expression in CRC TMAs (n = 420). Log-rank test was used. e Percentages of RNF138^high-pp65 N/C ratio^low (red) and RNF138^low-pp65 N/C ratio^high (blue) according to pTNM stage (1, 2, 3, 4) (n = 284). Correlation among RNF138, log(pp65 N/C), and pTNM stage (f), DFS (g), and OS (h) in CRC patient TMAs (n = 420). Log(N/C) indicates log(pp65 N/C). i Percentages of pTNM stage in RNF138^high-pp65 N/C ratio^low (n = 138) and RNF138^low-pp65 N/C ratio^high (n = 146) in CRC patient TMAs (n = 284). Correlation among RNF138, log(pp65 N/C), and pTNM stage (j), DFS (k), and OS (l) in CRC patient TMAs (n = 284). Log(N/C), log(pp65 N/C). m IHC analysis of pp65, ICAM1, and PTGS2 in low- and high-RNF138-expressing CRC samples. Scale bar, 100 μm. n Correlation between RNF138 mRNA levels and NF-κB target genes according to qPCR analysis. The formula, coefficient of correlation (r), and the P value were provided via Pearson’s test (n = 30)