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. 2022 Jun 13;13:3394. doi: 10.1038/s41467-022-31154-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a UMAP plots of APCs from iBAT of MMI mice (MMI group) and MMI mice treated with T3 at 0.5X standard dose for 4 d (T3 group). b Stacked bar chart showing relative abundance of cells from distinct groups (left) and from distinct states (right) in MMI group or T3 group. c, d Percentage of Dpp4⁺ APCs (c, left) and Icam1⁺ APCs (d, left) and number of Dpp4⁺ APCs (c, right) and Icam1⁺ APCs (d, right) (per mouse) in iBAT of MMI mice (n = 3) and MMI mice with daily T3 injection at 0.5X standard dose for 1 d (n = 4 for c and d, right; n = 3 for d, left) or 4 d (n = 4). e GO analysis of the up-regulated genes in T3 group vs MMI group. Bar chart showing the 10 most enriched biological processes. f Heatmap showing scaled average expression of genes belonging to GO:0006091 in Group 1–5 from MMI group and T3 group. Genes related to glycolysis are listed on the right. g Violin plots showing the expression levels and distribution of Myc, Hk2 and Pgk1, split by “orig.ident” (MMI group and T3 group). h Western blot analysis of Myc in cultured SVF cells from the iBAT of MTRαKO and MTRβKO mice with their corresponding Floxed mice. i Western blot analysis of Myc in cultured SVF cells from the iBAT of Floxed and MTRαKO mice with T3 treatment for indicated time. j Relative mRNA expression of Myc in cultured SVF cells (n = 6) or APCs (n = 3) from the iBAT of Floxed and MTRαKO mice. k ChIP-PCR analysis of the recruitment of HA-TRα to mouse Myc promoter in BAC cells after T3 treatment for 24 h. Means ± SEM are shown. P values were calculated by two-tailed unpaired Student’s t test for c, d, and j, and were calculated by hypergeometric distribution (two-tailed) and adjusted by Benjamini-Hochberg correction for e. NS, not significant. Source data are provided as a Source Data file.