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. 2022 Jun 13;12:9811. doi: 10.1038/s41598-022-14027-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of Liproxstatin-1-primed hUC-MSCs on murine macrophages. (a–c) Murine macrophages were co-cultured with hUC-MSCs in a trans-well system and ex vivo alveolar macrophages (a) and bone marrow-derived macrophages (b, c) were subjected to RT-qPCR analysis for mRNA evaluation of markers of polarized macrophages. Gapdh and Hprt1 were used as internal controls. Values in all the panels are mean ± SEM. All results are representative of at least three independent experiments. *p < 0.05, **p < 0.01, ns stands for not significantly different (by Kruskal Wallis test using GraphPad Prism 7, https://www.graphpad.com). Il-13 interleukin 13, Mmp-12 matrix metallopeptidase 12, Tgf-β transforming growth factor beta.