Table 1.

Association between IRGM polymorphisms and inflammatory conditions including cancer

Meta-analyses
Disease	Author	Population	Polymorphism	Association
CD	Li et al.[64]	Caucasian	rs13361189	Increases risk
			rs10065172, rs4958847	No association
	Lu et al. [65]	European	rs13361189, rs4958847 and rs10065172	Increases risk
Tuberculosis	Xie et al. [70]	Asian, African, African-American	rs10065172 (only in Asians), rs4958842, rs4859843 and rs4859846	Decreases risk
			rs72553867	No association

Case–control and cohort studies
Disease	Author	Population	Polymorphism	Association
Ankylosing spondylitis	Xia et al. [77]	Han Chinese, female	rs10065172	No association
			rs4958846	Decreases risk
AITD (Graves’ disease)	Yao et al. [74]	Chinese	rs10065172, rs4958847, and rs13361189	Increases risk
AITD (Hashimoto’s thyroiditis)			rs10065172, rs4958847, and rs13361189	No association
Candidiasis in HIV seropositive patients	Rosentul et al. [57]	Tanzanian	rs13361189 and rs4958847	No association
CD	Kee et al. [80]	Malaysian (Malay, Han Chinese, Indian)	rs4958847	No association
			rs11747270 A/G	Increases risk
			rs72553867	No association
	Teimoori-Toolabi et al. [81]	Iranian	rs10065171 and rs4958847	No association
	Pranculienė et al. [82]	Lithuanian	rs4958847	Increases risk
	Na et al. [83]	Korean (Early Onset CD)	rs1000113	Increases risk
			rs72553867	Decreases risk
			rs13361189, rs4958847 and rs10065172	No association
CD fistulising disease	Latiano et al. [67]	Italian	rs4958847	Increases risk
Frequency of CD Ileocolectomy	Sehgal et al. [68]	USA	rs4958847	Increases risk
Complications of postoperative CD Ileocolectomy	Kline et al. [69]	USA	rs13361189	Increases risk
Chronic periodontitis	Folwaczny et al. [76]	German	rs13361189, rs10065172, rs4958847, rs1000113 and rs931058	No association
			rs11747270	Increases risk
Clear cell renal cell carcinoma	Santoni et al. [62]	Italian	rs10059011	No association
Gastric cancer	Castaño-Rodríguez et al. [49]	Han Chinese	rs4958857	Decreases risk
			rs13361189	Increases risk
Gastric cancer	Burada et al. [60]	Romanian	rs4958857	Increases risk
			rs13361189	Decreases risk
Glioma	Ge et al. [61]	NA	rs13361189	Increases risk
			rs10065172	No association
Hepatic steatosis	Simon et al. [73]	Caucasian (Framingham Heart Study participants)	rs13361189	No association
Leprosy	Yang et al. [75]	Han Chinese	rs13361189	Increases risk
			rs4958842	No association
Mortality due to severe sepsis	Kimura et al. [79]	Japanese	rs10065172	Increases risk
NAFLD	Lin et al. [84]	Han Chinese (pediatric patients; 6–18 years old)	rs13361189, rs9637876, rs72553867, rs1000113, and rs11747270	No association
			rs10065172	Increases risk
Tuberculosis	Lu et al. [85]	Chinese	rs10065172, rs10051924 and rs13361189	Decreases risk
	Yuan et al. [86]	Han Chinese, Hubei Province	rs4958846	Decreases risk
			rs4958842 and rs4958843	No association
	Song et al. [87]	Korean	rs10065172	Decreases risk
			rs72553867 and rs12654043	No association
	Bahari et al. [88]	Iranian	rs4958843 and rs4958846	Decreases risk
			rs4958842	No association
	King et al. [89]	African-American	rs10065172	Increases risk
			rs11747270	Increases risk
UC	Palomino-Morales et al. [78]	Spanish	rs13361189 and rs4958847	Increases risk
VAT and NAFLD in patients presenting with CD	Simon et al. [72]	Prospective registry in inflammatory bowel Disease study at Massachusetts general hospital (PRISM) cohort	rs13361189 and rs4958847	Increases risk

CD Crohn’s disease; UC ulcerative colitis; NAFLD non-alcoholic fatty liver disease; AITD autoimmune thyroid disease; VAT visceral adipose tissue; HIV human immunodeficiency virus; NA not available