TABLE 1.
Baseline characteristics of patients.
| Characteristic | Patients without SAS, N = 31,294 | Patients with SAS, N = 1,026 | p-value |
| Male, n (%) | 19,000 (61%) | 805 (78%) | < 0.01 |
| Age (y), mean ± SD | 74 (12) | 70 (12) | < 0.01 |
| CPAP, n (%) | 1 (<0.1%) | 370 (36%) | < 0.01 |
| Past history | |||
| HT, n (%) | 19,189 (61%) | 925 (90%) | < 0.01 |
| DM, n (%) | 12,140 (39%) | 675 (66%) | < 0.01 |
| HF, n (%) | 7,618 (24%) | 647 (63%) | < 0.01 |
| Afor AFL, n (%) | 3,305 (11%) | 328 (32%) | < 0.01 |
| Laboratory data | |||
| Hb (g/dL), mean ± SD | 12.27 (2.19) | 12.60 (2.32) | < 0.01 |
| TP (mg/dL), mean ± SD | 6.98 (0.67) | 6.84 (0.69) | < 0.01 |
| Alb (mg/dL), mean ± SD | 3.88 (0.54) | 3.77 (0.57) | < 0.01 |
| Cre (mg/dL), mean ± SD | 1.61 (1.08) | 1.77 (1.26) | < 0.01 |
| eGFR (mL/min/1.73 m2), mean ± SD | 37 (14) | 37 (14) | 0.27 |
| KDIGO grade | 0.31 | ||
| G3a, n (%) | 10,695 (34%) | 323 (31%) | |
| G3b, n (%) | 11,196 (36%) | 387 (38%) | |
| G4, n (%) | 7,304 (23%) | 242 (24%) | |
| G5, n (%) | 2,099 (6.7%) | 74 (7.2%) | |
| BUN (mg/dL), mean ± SD | 27 (14) | 28 (14) | 0.01 |
| Na (mEq/L), mean ± SD | 140.3 (3.4) | 140.5 (3.2) | 0.49 |
| K (mEq/L), mean ± SD | 4.47 (0.60) | 4.40 (0.55) | < 0.01 |
| Cl (mEq/L), mean ± SD | 105.3 (4.3) | 105.0 (4.2) | < 0.01 |
| Primary outcome (composite), n (%) | 10,713 (34%) | 419 (41%) | < 0.01 |
| eGFR decline per year (min/min/1.73 m2), mean ± SD | 1.5 (8.5) | 2.1 (4.8) | 0.03 |
CPAP, continuous positive airway pressure therapy; HT, hypertension; DM, diabetes mellitus; HF, heart failure; Af, atrial fibrillation; AFL, atrial flutter; Hb, hemoglobin; TP, total protein; Alb, albumin; Cre, creatinine; eGFR, estimated glomerular filtration rate; BUN, blood urea nitrogen; Na, sodium; K, potassium; Cl, chloride.