Figure 5.

p63^high and p63^low groups recapitulate published HPV+ HNSCC subtype gene signatures. (A) Heatmap representation of expression of genes from the Keck et al. (14) signature within the p63^high and p63^low HPV+ HNSCC TCGA samples. DEGs are separated based on distinct patterns of expression between the p63^high and p63^low groups. Specific biological and signaling pathways associated with the DEGs are indicated. Bolded genes represent those that were included in the consensus p63-derived gene signature. (B) Heatmap representation of expression of genes from the Zhang et al. (11) signature within our p63^high and p63^low HPV+ HNSCC TCGA samples. DEGs are divided up by patterns of expression between the p63^high and p63^low groups. Specific biological and signaling pathways associated with the DEGs are indicated. Bolded genes represent those that were included in the consensus p63-derived gene signature. (C) Graph showing qRT-PCR results for normalized expression of 3 key genes in SCC104 cells expressing shCTL and p63 shRNAs.