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. 2022 May 31;12:879054. doi: 10.3389/fonc.2022.879054

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Copyright © 2022 Glathar, Oyelakin, Gluck, Bard and Sinha

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PIK3CA is amplified and mutated in p63^high tumors and affects PI3K signaling. (A) Bar graph comparing chromosome 3q status between p63^high and p63^low TCGA samples (p < 0.01). (B) Copy number alteration (CNA) frequencies in p63^high and p63^low TCGA samples (PIK3CA, p = 2.242e-3; SOX2, p = 0.0141; TP63, p = 0.0483). (C) Mutation frequencies in p63^high and p63^low TCGA samples (PIK3CA, p = 9.522e-3; TP53, p = 0.0482; TP63, p = 0.493). (D) Boxplot of the Winter hypoxia scores for p63^high and p63^low TCGA samples (p = 0.0121). (E) Heatmap of genes involved in PI3K signaling that were present in the combined cell line/TCGA based p63 signature. *p-value of ≤ 0.05, **p-value of ≤ 0.01, ns, non-significant.