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. 2022 May 31;9:898674. doi: 10.3389/fnut.2022.898674

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Copyright © 2022 Miao, Yu, Li, Sun and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The lipid-lowering mechanisms of C. militaris-derived polysaccharides. These polysaccharides are found to modulate multiple genes and proteins related to lipid absorption and metabolism in the plasma, small intestine, and liver, thereby improving hyperlipidemia and atherosclerosis. ABC, ATP-binding cassette; Apo, apolipoprotein; CRM, chylomicron remnant; FFA, free fatty acid; HSPG, heparan sulfate proteoglycan; IDL, intermediate density lipoprotein; LDL, low-density lipoprotein; LDLR, low-density lipoprotein receptor; LRP1, LDLR-related protein 1; LXRα, liver X receptor α; NPC1L1, Niemann-Pick C1-like protein 1; SR-B1, scavenger receptor B type 1; SREBP, sterol regulatory element-binding protein; VLDL, very low-density lipoprotein.