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. 2022 May 31;13:876291. doi: 10.3389/fimmu.2022.876291

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Copyright © 2022 Agostini, Orlacchio, Carbone and Guerriero

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Main strategies to overcome myeloid and Treg-mediated immunosuppression. Dendritic cells or inflammatory macrophages (TAMs M1) sustain the antitumor immune response through antigen presentation. Myeloid-derived suppressor cells (MDSCs), anti-inflammatory tumor-associated macrophages (TAMs M2), and regulatory T (Treg) cells regulate these processes by exploiting inhibitory pathways, thus establishing an immunosuppressive tumor microenvironment. Some of the most clinically relevant therapeutic strategies available to target those pathways are reported. Created with BioRender.com.