TABLE 2.

Plasma levodopa (LD) concentrations and pharmacokinetics (PK) parameters, unadjusted and adjusted by body weight, measured in men and women.

Plasma LD concentration measured at each time point (ng/mL)				Plasma LD concentration measured at each time point corrected by BW (ng/mL)/w
Time (min.)	M	W	P-value	Time (min.)	M	W	P-value
20	454.1053 ± 5583.694	1168.42 ± 11220.535	0.0313	20	5.936316 ± 0.93631635	18.14667 ± 819.6273	0.0189
40	732.1368 ± 32.136835	2284.08 ± 1846.953	0.0014	40	9.411579 ± 0.6.893599	34.02933 ± 426.90424	0.0005
60	662.7263 ± 62.726324	1305.037 ± 305.03724	0.0080	60	8.817368 ± 0.8.099045	19.63 ± 912.91515	0.0049
80	459.0368 ± 59.036815	957.55 ± 57.556815	0.0016	80	5.974211 ± 0.4.441285	14.315 ± 48.191977	0.0005
125	324.9421 ± 24.942177	640.9813 ± 4385.7052	0.0035	125	4.402105 ± 0.3.1499	9.516875 ± 0.5.957967	0.0027
170	228.0568 ± 2159.6823	400.2706 ± 00.270623	0.0134	170	3.094211 ± 0.2.54934	5.9375 ± 0.3.454692	0.0085
215	153.3053 ± 53.305392	398.5067 ± 98.506792	0.0000	215	2.066842 ± 0.1.515395	5.848 ± 2.600281	0.0000
260	115.5556 ± 15.555628	229.1933 ± 296.75774	0.0008	260	1.572222 ± 0.1.235321	3.414 ± 0.1.520925	0.0006
PK parameters				PK parameters corrected by BW
AUC mcg*h/mL	1.126805 ± 0.126805et	2.583994 ± 0.51.49891	0.0006	AUC/w (mcg*h/mL)/w	0.0147789 ± 0.00996	0.0387062 ± 0.0.02404	0.0385
Cmax ng/mL	909.8947 ± 09.89474 4	2405.094 ± 405.09447	0.0014	Cmax/w (ng/mL)/w	12.15474 ± 2.15474	36.31375 ± 6.31375w	0.0004
Tmax min.	45.26316 ± 5.26316w	46.25 ± 6.25316w	NS
t1/2 hours	1.533158 ± 0.0.534977	1.494375 ± 0.1.237298	NS

Values are expressed as mean ± SD.

Abbreviations: LD, levodopa; BW, body weight; PK, pharmacokinetics; AUC, area under the curve; Cmax, maximum plasma concentration; Tmax, time to reach Cmax; t_1/2, half-life; AUCw, AUC adjusted for body weight; Cmax/w, Cmax adjusted for body weight.