TABLE 3.

Differences in plasma LD concentrations and PK parameters between men and women stratified by the BMI median value.

BMI < 26				BMI ≥ 26
Plasma LD concentration measured at each time point (ng/ml)
Time (min.)	M	W	P-value	Time (min.)	M	W	P- value
20	411.1375 ± 11.1375D	1812.371 ± 812.371D	0.0168	20	485.3545 ± 85.3545D	604.962576 ± 04.962576	NS
40	707.75 ± 07.75 576	2785.6 ± 785.6 576	0.0121	40	749.8727 ± 49.872776	1845.25 ± 845.25 76	NS
60	798.425 ± 98.425 76	1732.271 ± 732.27176	0.0262	60	564.0364 ± 64.036476	972.7444 ± 72.744476	NS
80	487.275 ± 87.275476	1227.457 ± 227.45776	0.0010	80	438.5 ± 38.505776	747.6222 ± 47.622276	NS
125	357.7 ± 215.7421	802.7571 ± 02.757121	0.0367	125	301.1182 ± 01.118221	515.1556 ± 15.1556 1	0.0345
170	298.025 ± 98.0256 1	444.2714 ± 44.2714 1	NS	170	177.1709 ± 77.1709 1	366.0478 ± 66.0478	0.0292
215	198.9875 ± 98.9875 1	433.35 ± 33.35 5	0.0056	215	120.0818 ± 68.60688	375.2778 ± 192.1556	0.0006
260	140.05 ± 40.05 155	249.75 ± 80.20506	0.0441	260	95.96 ± 5.961 506	215.4889 ± 15.4889 6	0.0082
PK parameters
AUC mcg*h/mL	1.216038 ± 0.216038me	3.332286 ± 0.332286 et	0.0050	AUC mcg*h/mL	1.061909 ± 0.061909 et	2.001989 ± 0.001989 e	0.0385
Cmax ng/mL	941.5125 ± 41.5125 et	2986.786 ± 986.786	0.0149	Cmax ng/mL	886.9 ± 86.9 6 e	1952.667 ± 952.667 et	0.0474
Tmax min.	57.5 ± 7.574 7 e	40 ± 0 5	NS	Tmax min.	38.18182 ± 8.18182 e	62.22222 ± 0.22222 e	NS
t1/2 hours	1.4225 ± 0.4225 2 e	1.051429 ± 0.051429 e	NS	t1/2 hours	1.613636 ± 0.613636 et	1.838889 ± 0.838889 e	NS

Values are expressed as mean ± SD.

Abbreviations: LD, levodopa; PK, pharmacokinetics; AUC, area under the curve; Cmax, maximum plasma concentration; Tmax, time to reach Cmax; t_1/2, half-life.