Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 31;13:879754. doi: 10.3389/fimmu.2022.879754

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhou, Li, Liu, Zhu and Peng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The activation of mast cells and basophils in patients with chronic spontaneous urticaria mediated by autoantibodies. Mast cells and basophils are activated by IgE antibodies against its high-affinity receptor (FcϵRI) or IgG antibodies against IgE/FcϵRI and release several mediators [i. e. histamine, tryptase, Leukotriene C4 (LTC4), prostaglandin D2 (PGD2), platelet-activating factor (PAF), granulocyte-macrophage colony-stimulating factor (GM-CSF), matrix metalloproteinase-9 (MMP-9), C-X-C motif chemokine ligand 1/2 (CXCL1/2), tumor necrosis factor α (TNFα), etc.] that concur to produce the marked vasodilation that stands at the basis of both wheal-and flare reaction and angioedema.