Figure 2.

SARS-CoV-2 convalescent plasma reactivity against the SARS-CoV-2 Washington strain PSV. (A–F) Plasma titrations on the HEK293_ACE2 (right axis in gray, % neutralization) and HEK293_ FcγRIIa (left axis in green, fold increase in viral entry in the presence of plasma) target cell lines. Representative titers show relationship between FVE and neutralization for (A–C) individuals that mediate FVE and neutralization, (D) and (E) individuals that only mediate neutralization, and (F) healthy donor plasma. (G) Correlation between the FVE endpoints of max FVE and FVE AUC used to define plasma as FVE mediating (upper right quadrant). Convalescent plasma samples are shown as circles and pre-pandemic, healthy human plasma samples are shown as ‘X’ symbols. (H) Percentages of plasma mediating FVE and/or neutralization against the SARS-CoV-2 Washington strain PSV. (I) Spearman correlation between the FVE endpoint of plasma dilution at which max FVE was observed and neutralization ID₅₀.