REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit anti-CX43	Cell Signaling Technology	Cat#3512S; RRID: AB_2294590
Rabbit monoclonal anti-VDAC (D73D12)	Cell Signaling Technology	Cat#4661; RRID: AB_10557420
Rabbit monoclonal anti-RIG-I (D14G6)	Cell Signaling Technology	Cat#3743; RRID: AB_2269233
Rabbit monoclonal anti-MDA5 (D74 × 104)	Cell Signaling Technology	Cat#5321; RRID: AB_10694490
Rabbit anti-SOD1	Cell Signaling Technology	Cat#2770; RRID: AB_2302392
Rabbit monoclonal anti-MAVS (D5A9E, H)	Cell Signaling Technology	Cat#24930; RRID: AB_2798889
Rodent specific anti-MAVS (Mouse/Rat)	Cell Signaling Technology	Cat#4983; RRID: AB_823566
Rabbit monoclonal anti-COX IV (3 × 1011)	Cell Signaling Technology	Cat#4850; RRID: AB_2085424
Rabbit monoclonal anti-STAT1 (D1K9Y)	Cell Signaling Technology	Cat#14994; RRID: AB_2737027
Rabbit monoclonal anti-STING (D2P2F)	Cell Signaling Technology	Cat#13647; RRID: AB_2732796
Rabbit monoclonal anti-TBK1/NAK (D1B4)	Cell Signaling Technology	Cat#3504; RRID: AB_2255663
Rabbit monoclonal anti-phoshoTBK1/NAK1 (Ser172, D52C2)	Cell Signaling Technology	Cat#5483; RRID: AB_10693472
Rabbit monoclonal anti-phospho-IRF3 (Ser396, 4D4G)	Cell Signaling Technology	Cat#4947; RRID: AB_823547
Mouse monoclonal anti-dsDNA [35I9 DNA]	Abcam	Cat#ab27156; RRID: AB_470907
Rabbit polyclonal anti-DDX41	ABclonal Inc.	Cat#A6576; RRID: AB_2767170
Rabbit polyclonal Lamin A/C [KO validated]	ABclonal Inc.	Cat#A0249; RRID: AB_2757062
Rabbit polyclonal anti-HSP60/HSPD1	ABclonal Inc.	Cat#A0969; RRID: AB_2757488
Rabbit polyclonal anti-IRF3 [KO validated]	ABclonal Inc.	Cat#A11118; RRID: AB_2861504
Rabbit polyclonal anti-PANX1	ABclonal Inc.	Cat#A13587; RRID: AB_2760449
Rabbit polyclonal anti-GJC1/CX45	ABclonal Inc.	Cat#A7053; RRID: AB_2767608
Rabbit polyclonal anti-cGAS	ABclonal Inc.	Cat#A8335; RRID: AB_2770305
Rabbit polyclonal anti-phospho-cGAS Y215	ABclonal Inc.	Cat#AP0946; RRID: N/A
Mouse monoclonal anti-FLAG (M2)	Sigma-Aldrich	Cat#F1804; RRID: AB_262044
Mouse monoclonal anti-O4	Sigma-Aldrich	Cat#O7139; RRID: AB_477662
Mouse monoclonal anti-CD45 (clone 30-F11)	BD Pharmingen	Cat#550539; RRID: AB_2174426
Sheep polyclonal anti-ITGB5	R&D Systems	Cat#AF3824; RRID: AB_1151977
Mouse monoclonal anti-L1, clone 324	Millipore Sigma	Cat#MAB5272; RRID: AB_2133200
Mouse monoclonal anti-DNA:RNA hybrid, clone S9.6	Millipore Sigma	Cat#MABE1095; RRID: AB_2861387
Mouse monoclonal anti-NK1.1	Thermo Fisher Scientific	Cat#MA1-70100; RRID: AB_2296673
Mouse monoclonal anti-NF-κB p65 (F-6)	Santa Cruz Biotechnology	Cat#sc-8008; RRID: AB_628017
Mouse monoclonal anti-mtTFA (F6)	Santa Cruz Biotechnology	Cat#sc-166965; RRID: AB_10610743
Mouse monoclonal anti-Pol II (A10)	Santa Cruz Biotechnology	Cat#sc-17798; RRID: AB_677355
Rabbit polyclonal anti-TOM20 (FL-145)	Santa Cruz Biotechnology	Cat#sc-11415; RRID: AB_2207533
Mouse monoclonal anti-GFAP	Santa Cruz Biotechnology	Cat#sc-33673; RRID: AB_627673
Mouse monoclonal anti-Iba1	Santa Cruz Biotechnology	Cat#sc-32725; RRID: AB_667733
Mouse monoclonal anti-CD4	Santa Cruz Biotechnology	Cat#sc-19641; RRID: AB_2009035
Mouse monoclonal anti-CD19	Santa Cruz Biotechnology	Cat#sc-; RRID: AB_667733
Mouse monoclonal anti-β-Actin (C4)	Santa Cruz Biotechnology	Cat#sc-47778; RRID: AB_2714189
Mouse monoclonal anti-β-tubulin (G8)	Santa Cruz Biotechnology	Cat#sc-55529; RRID: AB_2210962
Mouse monoclonal anti-CD68	Santa Cruz Biotechnology	Cat#sc-20060; RRID: AB_627158
Mouse monoclonal anti-VP1 Clone 31A2	Mediagnost	Cat#M47; RRID: N/A
InVivoMAb anti-mouse IFNAR-1	Bio X Cell	Cat#BE0241; RRID: N/A
InVivoMAb anti-mouse CCL2 (MCP-1)	Bio X Cell	Cat#BE0185; RRID: N/A
Bacterial and virus strains
CVB3	ATCC	Cat#VR-300
HCoV-OC43	ATCC	Cat#VR-1558
Chemicals, peptides, and recombinant proteins
RPMI Medium 1640 (1X)	Gibco	Cat#11875-093
RPMI Medium 1640 D-Glucose (−)	Gibco	Cat#11879-020
Fetal Bovine serum (FBS)	Gibco	Cat#12483-020
HEPES (1M) pH 7.5	Gibco	Cat#15630-080
2-mercaptoethanol (1000X)	Gibco	Cat#21985-023
N2-supplement (100X)	Thermo Fisher	Cat#17502-048
B-27 supplement (50X), serum free	Thermo Fisher	Cat#17504044
Cyclosporin A (CsA)	Sigma-Aldrich	Cat#SML1018
Heparin-Binding EGF-Like Growth Factor	Sigma-Aldrich	Cat#E4643
LFM-A13	Sigma-Aldrich	Cat#435300
2′,3′-Dideoxycytidine (ddC)	Sigma-Aldrich	Cat#D5782
Corn oil	Sigma-Aldrich	Cat#C8267
Tween-80	Sigma-Aldrich	Cat#P4780
Dimethyl sulfoxide	Sigma-Aldrich	Cat#D8418
Dexamethasone	Sigma-Aldrich	Cat#D4902
Carbenoxolone disodium salt	Sigma-Aldrich	Cat#C4790
Brefeldin A	Sigma-Aldrich	Cat#B5936
Probenecid	Sigma-Aldrich	Cat#P3000000
DMEM	Sigma-Aldrich	Cat#D6429
DMEM Ham’s:F12 Mixture	Sigma-Aldrich	Cat#51445C
Dulbecco’s PBS	Sigma-Aldrich	Cat#D8662
Penicillin-Streptomycin	Sigma-Aldrich	Cat#P4333
Sodium pyruvate solution	Sigma-Aldrich	Cat#S8636
Hematoxylin solution Gill No.2	Sigma-Aldrich	Cat#GHS232
Herring testes (HT)-DNA	Sigma-Aldrich	Cat#D6898
Digitonin	Sigma-Aldrich	Cat#D141
Tunicamycin	Abcam	Cat#ab120296
RNase H	NEB	Cat#0297S
DNase I	NEB	Cat#M0303S
IFN-β-human recombinant proteins	Bio Basic Canada	Cat#RC217-16
Image-iT FX Signal Enhancer	Invitrogen	Cat#I36933
UltraPure™ Ethidium Bromide	Invitrogen	Cat#15585011
Lipofectamine 2000	Invitrogen	Cat#11668027
Lipofectamine RNAiMAX	Invitrogen	Cat#13778075
Normocin™	Invivogen	Cat#ant-nr-1
High molecular weight poly(I:C)	Invivogen	Cat#tlrl-pic
Protease inhibitor cocktail tablets	Roche	Cat#05892791001
DNAfectin™ Plus	ABM Canada	Cat#G2500
TransIT-X2 Dynamic Delivery System	Mirus Bio	Cat#MIR 6004
TNFR1 Blocking Peptide	Fitzgerald	Cat#33R-10641
RU.521	Cayman Chemical	Cat#31765
C-176	Cayman Chemical	Cat#25859
H-151	Cayman Chemical	Cat#25857
Fluo-cGAMP	BIOLOG Life Science Institute	Cat#C195-001
Protein G-SepharoseTM 4 Fast Flow	GE Healthcare Biosciences	Cat#17-0618
Critical commercial assays
CyQuant™ LDH Cytotoxicity kit	Thermo Fisher	Cat#C20301
POWER SYBR® Green RNA-to-CTTM kit	Thermo Fisher	Cat#4389986
ATP assay kit	Sigma-Aldrich	Cat#MAK190
MMP-assay kit	Sigma-Aldrich	Cat# MAK147-1KT
Universal Mycoplasma detection kit	ATCC	Cat#30-1012K
QIAGEN Plasmid Plus kit	QIAGEN	Cat#12941
RNeasy Mini-extraction kit	QIAGEN	Cat#74104
QIAmp DNA Mini Kit	QIAGEN	Cat#51304
Mouse ChAT ELISA Kit	Antibodies.com	Cat#A77879
QuicKey Mouse IgG ELISA Kit	Elabscience	Cat#E-TSEL-M0003
Mouse IgM ELISA Kit	Elabscience	Cat#E-EL-M3036
Mouse ANA (Anti-Nuclear Antibody) ELISA	MyBioSource	Cat#MBS261480
2′3′-cGAMP ELISA Kit	Cayman Chemical	Cat#501700
VeriKine mouse IFN Beta ELISA Kit, High Sensitivity	PBL Assay Science	Cat#42410-1
Deposited data
RAW and analyzed data	This paper	GEO: GSE167974
Experimental models: Cell lines
HeLa	ATCC	Cat#CCL-2.2; RRID: CVCL_0030
U2-OS	ATCC	Cat#HTB-96; RRID: CVCL_0042
HEK293T	ATCC	Cat#CRL-3216; RRID: CVCL_0063
THP-1	ATCC	Cat#TIB-202; RRID: CVCL_0006
RAW264.7	ATCC	Cat#TIB-71; RRID: CVCL_0493
SH-SY5Y	ATCC	Cat#CRL-2266; RRID: CVCL_0019
Neuro2a	ATCC	Cat#CCL-131; RRID: CVCL_0470
SIM-A9	ATCC	Cat#CRL-3265; RRID: CVCL_5I31
HASTR/ci35	From Dr. Tomomi Furihata (TUPLS, Japan)	Cat#N/A; RRID: CVCL_4U69; (Furihata et al., 2016; Kitamura et al., 2018)
C20	From Dr. David Alvarez-Carbonell (CWRU, USA)	Cat#N/A; RRID: N/A; (Garcia-Mesa et al., 2017)
NSC-34	From Dr. Neil R. Cashman (UBC, Canada)	Cat#N/A; RRID: CVCL_D356; (Cashman et al., 1992)
MO3.13	From Dr. Neil R. Cashman (UBC, Canada)	Cat#N/A; RRID: CVCL_D357; (McLaurin et al., 1995)
Experimental models: Organisms/strains
Wild-type C57BL/6J background mice	The Jackson Laboratory	Cat#000664
B6.Cg-Tg (SOD1∗G85R)148Dwc/J mice	The Jackson Laboratory	Cat#008248
B6.Cg-Tg(SOD1∗G93A)1Gur/J mice	The Jackson Laboratory	Cat#004435
B6.Cg-Tmem173tm1.2Camb/J mice	The Jackson Laboratory	Cat#025805
Oligonucleotides
HCoV-OC43 Nucleocapsid (N): F: CGATG AGGCTATTCCGACTAGGT R: CCTTCCTGAGCCTTCAATATAGTAACC	Integrated DNA Technologies (IDT)	(Hammitt et al., 2011)
CVB3 2A gene: F: GCTTTGCAGACATCCGTGATC R: CAAGCTGTGTTCCACATAGTCCTTCA	Integrated DNA Technologies (IDT)	N/A
CVB3 VP1 gene: F: ACATGGTGCGAAGAGTCTATTGAG R: TGCTCCGCAGTTAGGATTAGC	Integrated DNA Technologies (IDT)	N/A
Murine IFNA4 gene: F: CTGCTACTTGGAATGCAACTC R: CAGTCTTGCCAGCAAGTTGG	Integrated DNA Technologies (IDT)	(Mattei et al., 2013)
Murine IFNB1 gene: F: GCCTTTGCCATCCAAGAGATGC R: ACACTGTCTGCTGGTGGAGTTC Human IFNB1 gene: F: CAACTTGCTTGGATTCCTACAAAG R: TATTCAAGCC TCCCATTCAATTG	Integrated DNA Technologies (IDT)	N/A
Murine RSAD2 gene: F: TGGGGATGCTGGTGCCCACT R: ACCCCGGACCTGTGGCTGTT Human RSAD2 gene: F: TTGGACATTCTCGCTATCTCCT R: AGTGCTTTGAT CTGTTCCGTC	Integrated DNA Technologies (IDT)	N/A
Murine ISG15 gene: F: CAAGCAGCCAGAAGCAGACT R: CCCAGCATCTTCACCTTTAGG Human ISG15 gene: F: CGCAGATCACCCAGAAGATCG R: TTCGTCGCAT TTGTCCACCA	Integrated DNA Technologies (IDT)	N/A
Murine TNF gene: F: GTCCCCAAAGGGATGAGAAGTT R: GTTTGCTACGACGTGGGCTACA Human TNF gene: F: CCTCTCTCTAATCAGCCCTCTG R: GAGGACCTGG GAGTAGATGAG	Integrated DNA Technologies (IDT)	N/A
Murine CXCL10 gene: F: GCTGGGATTCACCTCAAGAA R: CTTGGGGACACCTTTTAGCA Human CXCL10 gene: F: GTGGCATTCAAGGAGTACCTC R: TGATGGCCTTC GATTCTGGATT	Integrated DNA Technologies (IDT)	N/A
Human CCL3 gene: F: ATGCAGGTCTCCACTGCTGCCCTT R: GCACTCAGCTCCAGGTCGCTGACAT	Integrated DNA Technologies (IDT)	(Chui and Dorovini-Zis, 2010)
Murine CCL5 gene: F: GCTGCTTTGCCTACCTCTCC R: TCGAGTGACAAACACGACTGC	Integrated DNA Technologies (IDT)	N/A
Murine IL-6 gene: F: ACAACCACGGCCTTCCCTAC R:TCTCATTTCCACGATTTCCCAG Human IL-6 gene: F: ACTCACCTCTTCAGAACGAATTG R: CCATCTTT GGAAGGTTCAGGTTG	Integrated DNA Technologies (IDT)	N/A
Murine IL-1B gene:F: GCAACTGTTCCTGAACTCAACT R: ATCTTTTGGGGTCCGTCAACT Human IL-1B gene: F: CCACAGACCTTCCAGGAGAATG R: GTGCAGTTC AGTGATCGTACAGG	Integrated DNA Technologies (IDT)	N/A
Human NOS2 gene: F: AGGGACAAGCCTACCCCTC R: CTCATCTCCCGTCAGTTGGT	Integrated DNA Technologies (IDT)	N/A
Human IRF7 gene: F: GCTGGACGTGACCATCATGTA R: GGGCCGTATAGGAACGTGC	Integrated DNA Technologies (IDT)	N/A
Human TNFAIP3 gene: F: TTGTCCTCAGTTTCGGGAGAT R: ACTTCTCGACACCAGTTGAGTT	Integrated DNA Technologies (IDT)	N/A
Murine AXL gene: F: ATGGCCGACATTGCCAGTG R: CGGTAGTAATCCCCGTTGTAGA	Integrated DNA Technologies (IDT)	(Zou et al., 2020)
Murine B2M gene: F: ACAGTTCCACCCGCCTCACATT R: TAGAAAGACCAGTCCTTGCTGAAG	Integrated DNA Technologies (IDT)	N/A
Murine AIF1 gene: F: TCTGCCGTCCAAACTTGAAGCC R: CTCTTCAGCTCTAGGTGGGTCT	Integrated DNA Technologies (IDT)	N/A
Human IBA1 gene: F: CCCTCCAAACTGGAAGGCTTCA R: CTTTAGCTCTAGGTGAGTCTTGG	Integrated DNA Technologies (IDT)	N/A
Human CD11B gene: F: GGAACGCCATTGTCTGCTTTCG R: ATGCTGAGGTCATCCTGGCAGA	Integrated DNA Technologies (IDT)	N/A
Murine SLC1A2 gene: F: ACAATATGCCCAAGCAGGTAGA R: CTTTGGCTCATCGGAGCTGA	Integrated DNA Technologies (IDT)	N/A
Murine GFAP gene: F: CGGAGACGCATCACCTCTG R: AGGGAGTGGAGGAGTCATTCG	Integrated DNA Technologies (IDT)	N/A
Murine FGFR3 gene: F: GGAGGACGTGGCTGAAGAC R: GGAGCTTGATGCCCCCAAT	Integrated DNA Technologies (IDT)	N/A
Murine AQP4 gene: F: CTTTCTGGAAGGCAGTCTCAG R: CCACACCGAGCAAAACAAAGAT	Integrated DNA Technologies (IDT)	N/A
Murine GJB6 gene: F: ACCAGCATAGGGAAGGTGTG R: TGCAGAGTGTTGCAGACAAAG	Integrated DNA Technologies (IDT)	N/A
Murine GJC2 gene: F: TCCACAATCATTCCACCTTCG R: CAGAAGCGCACATGAGACAG	Integrated DNA Technologies (IDT)	N/A
Murine SOX10 gene: F: ACACCTTGGGACACGGTTTTC R: TAGGTCTTGTTCCTCGGCCAT	Integrated DNA Technologies (IDT)	N/A
Murine SIGLEC4A gene: F: CTGCCGCTGTTTTGGATAATGA R: CATCGGGGAAGTCGAAACGG	Integrated DNA Technologies (IDT)	N/A
Murine MOG gene: F: `AGCTGCTTCCTCTCCCTTCTC R: ACTAAAGCCCGGATGGGATAC	Integrated DNA Technologies (IDT)	N/A
Murine MBP gene: F: GGCGGTGACAGACTCCAAG R: GAAGCTCGTCGGACTCTGAG	Integrated DNA Technologies (IDT)	N/A
Murine HB9/MNX1 gene: F: CAGCACCTTCCAACTGGACCAG R: TTCGGCACTTCCCCAAGAGGTT	Integrated DNA Technologies (IDT)	N/A
Murine ISL1 gene: F: GGTCTCTGGAACATCCCACATTGT R: CTGTTCCTACTCCCCATTCACT	Integrated DNA Technologies (IDT)	N/A
Murine CHAT gene: F: GCTTGAATGGAGCGAATCGTTGG R: CACCAGGACGATGCCATCAAAAG	Integrated DNA Technologies (IDT)	N/A
Murine ACTB gene: F: CATTGCTGACAGGATGCAGAAGG R: TGCTGGAAGGTGGACAGTGAGG Human ACTB gene: F: ACTGGAACGGTGAAGGTGAC R: GTGGACTTGGGA GAGGACTG	Integrated DNA Technologies (IDT)	N/A
MT-DNA D-LOOP: F: AATCTACCATCCTCCGTGAAACC R: TCAGTTTAGCTACCCCCAAGTTTAA	Integrated DNA Technologies (IDT)	N/A
MT-DNA MT-CO1: F: GACGTAGACACACGAGCATATTTCA R: AGGACATAGTGGAAGTGAGCTACAAC	Integrated DNA Technologies (IDT)	N/A
MT-DNA MT-ND1: F: CCACCTCTAGCCTAGCCGTTTA R: GGGTCATGATGGCAGGAGTAAT	Integrated DNA Technologies (IDT)	N/A
MT-DNA MT-ATP6: F: TAGCCATACACAACACTAAA GGACGA R: GGGCATTTTTAATCTTAGAGCGAAA	Integrated DNA Technologies (IDT)	N/A
Nuclear TERT gene: F: CTAGCTCATGTGTCAAGACCC TCTT R: GCCAGCACGTTTCTCTCGTT	Integrated DNA Technologies (IDT)	N/A
RIG-I/DDX58 sgRNA (Human): 5′-GGATTAT ATCCGGAAGACCC-3′	Applied Biological Materials Inc.	N/A
MDA5/IFIH1 sgRNA (Human): 5′-CGAATTCC CGAGTCCAACCA-3′	Applied Biological Materials Inc.	(Ng et al., 2020)
MAVS sgRNA (Human): 5′-ATTGCGGCAGAT ATACTTAT-3′	Applied Biological Materials Inc.	N/A
GJA1 (CX43) sgRNA (Human): 5′-CTTGTCAA GGAGTTTGCCTA-3′	Applied Biological Materials Inc.	N/A
GJC1 (CX45) sgRNA (Human): 5′-ATCGTCCTT ACAGCTGTAGG-3′	Applied Biological Materials Inc.	N/A
GJD2 (CX36) sgRNA (Human): 5′-AGCACTCCA CTATGATCGGG-3′	Applied Biological Materials Inc.	N/A
PANX1 sgRNA (Human): 5′-AATCGAGATCTC CTGCGCGA-3′	Applied Biological Materials Inc.	N/A
TBK1 sgRNA (Human): 5′-AGAGCACTTCTAA TCATCTG-3′	Applied Biological Materials Inc.	N/A
IRF3 sgRNA (Human): 5′-TTGGAAGCACGG CCTACGGC-3′	Applied Biological Materials Inc.	N/A
TICAM1/TRIF sgRNA (Human): 5′-GTAGGCC ACGTCCCGCAGCG-3′	Applied Biological Materials Inc.	N/A
cGAS/MAB21L3 sgRNA (Human): 5′-ATGGC CTTTCCGTGCCA-3′	Applied Biological Materials Inc.	N/A
STING/TMEM173 sgRNA (Human): 5′-ACGGG ATGGATGGATGC-3′	Applied Biological Materials Inc.	N/A
STAT1 sgRNA (Human): 5′-TCCCATTACAGG CTCAGTCG-3′	Applied Biological Materials Inc.	N/A
TFAM sgRNA (Human): 5′-GCGTTTCTCCG AAGCATGTG-3′	Applied Biological Materials Inc.	N/A
DDX41 sgRNA (Human): 5′-AAGAGCGACAT GAGCGCGTG-3′	Applied Biological Materials Inc.	N/A
siRNAs targeting human PPID gene: ID: s10913, s10914, and s10915	Thermo Fisher	Cat#4390824
siRNAs targeting human ZBP1 gene: ID: s37484, and s37485	Thermo Fisher	Cat#4390420
siRNAs targeting human IFI16 gene: ID: s7136, and s7137	Thermo Fisher	Cat#4392420
Recombinant DNA
p125-Luciferase reporter (IFN-β)	From Dr. Takashi Fujita (Kyoto University, Japan)	(Yoneyama et al., 1998)
p55C1B-Luciferase reporter (IRF3)	From Dr. Takashi Fujita (Kyoto University, Japan)	(Narita et al., 2014)
p55A2-Luciferase reporter (NF-κB)	From Dr. Takashi Fujita (Kyoto University, Japan)	(Narita et al., 2014)
pEF-Tak-Flag-MAVS	From Dr. Takashi Fujita (Kyoto University, Japan)	(Onoguchi et al., 2010)
pEF-Flag-IRF3 5D	From Dr. Takashi Fujita (Kyoto University, Japan)	(Mori et al., 2004)
pcDNA-Flag-cGAS WT, ΔcGAMP, ΔDNA, K394E, and Y215E.	From Dr. Nelson O. Gekara (Stockholm University, Sweden)	(Jiang et al., 2019)
pEGFP-SOD1-WT, G93A, and G85R	From Dr. Neil R. Cashman (UBC, Canada)	(Pokrishevsky et al., 2017)
pcDNA-Flag-SOD1-WT, A4V, G37R, H46R, E100G, G93A, G85R, V148G, V148I, and G127X	From Dr. Christine Vande Velde (Université deMontréal, Canada)	(Semmler et al., 2020)
pGL4.32 (luc2P/NF-κB-RE/Hygro)	Promega	Cat#E8491
pRL-TK Renilla Luciferase Control reporter vector	Promega	Cat#E2231
Software and algorithms
Prism version 8.0	GraphPad	https://www.graphpad.com/
Microsoft Office Home and Student 2019	Microsoft Corporation	https://www.microsoft.com/microsoft-365
Adobe Illustrator 2020	Adobe Inc.	http://www.adobe.com