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. 2022 Jun 10;15(6):dmm049517. doi: 10.1242/dmm.049517

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — Genetic rescue of PNP closure defects in the Pax3-Cre;Lrp6-cKOs by β-catenin gain-of-function (GOF). (A,B) Failed PNP closure as shown in the dorsal–posterior view of an Lrp6-cKO embryo (A) and in a transverse PNP section (arrows in B, cut through the dashed line in A) at E10.5. (C,D) Rescued PNP closure as shown in the dorsal–posterior view of an Lrp6-cKO;β-catenin-GOF embryo (A) and in a transverse PNP section that shows abnormally widened but closed dorsal PNP (arrowhead in D, cut through the dashed line in C) at E10.5. (E) A transverse PNP section of a littermate control embryo shows normally closed PNP at the dorsal midline (arrowhead in E) at E10.5.