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. 2022 May 31;37(23):e180. doi: 10.3346/jkms.2022.37.e180

Table 3. Cox proportional hazard model for early responsiveness of the priming ChAdOx1 vaccination.

Variables Adjustment for age and sex
HR 95% CI P value
Body mass index, kg/m2 1.022 0.970–1.076 0.413
SBP at initiation of HD, mmHg 0.998 0.993–1.003 0.528
DBP at initiation of HD, mmHg 0.999 0.990–1.009 0.901
Cause of end-stage renal disease
Diabetes mellitus 0.908 0.600–1.375 0.649
Hypertension 1.052 0.682–1.621 0.819
Chronic glomerulonephritis 0.723 0.574–0.911 0.006
Others 1.579 0.824–3.028 0.169
Medical history
Vintage, mon 1.001 0.999–1.003 0.312
Charlson comorbidity index 0.936 0.810–1.082 0.370
Cardiovascular disease 0.943 0.620–1.435 0.784
Cerebrovascular disease 1.082 0.442–2.651 0.863
Mycophenolate mofetil user 0.696 0.528–0.917 0.010
Breast cancer 3.693 1.992–6.846 < 0.001
Diabetic (vs. non-diabetic) 0.979 0.609–1.572 0.929
Hypertensive (vs. non-hypertensive) 1.047 0.702–1.561 0.821
ARB use (vs. non-use) 0.869 0.593–1.274 0.473
CCB use (vs. non-use) 1.150 0.801–1.652 0.448
β-blocker use (vs. non-use) 0.907 0.649–1.267 0.567
α-blocker use (vs. non-use) 1.268 0.475–3.382 0.636
Sulfonylurea use (vs. non-use) 0.793 0.363–1.732 0.561
DPP-4 inhibitor Use (vs. non-use) 0.869 0.526–1.437 0.585
Statin use (vs. non-use) 1.212 0.854–1.722 0.282
Steroid use (vs. non-use) 0.719 0.590–0.876 0.001
Vitamin D use (vs. non-use) 0.688 0.261–1.811 0.449
ESA use (vs. non-use) 0.999 0.526–1.865 0.976
Laboratory test
White blood cell, 109/L 1.022 0.970–1.076 0.365
Hemoglobin, g/dL 0.866 0.600–1.249 0.441
Platelet, 103/μL 1.002 0.998–1.005 0.329
Neutrophil, 109/L 1.105 0.954–1.280 0.605
Lymphocyte, 109/L 1.113 0.723–1.714 0.261
Sodium, mmol/L 1.044 0.968–1.127 0.262
Potassium, mmol/L 0.763 0.453–1.287 0.311
Chloride, mmol/L 1.012 0.949–1.080 0.717
Total CO2, mmol/L 1.034 0.969–1.104 0.306
Total protein, g/dL 0.984 0.774–1.251 0.894
Albumin, g/dL 1.207 0.579–1.824 0.927
Corrected calcium, mg/dL 0.776 0.627–0.961 0.020
Phosphorus, mg/dL 0.972 0.859–1.100 0.652
Fasting blood glucose, mg/dL 0.999 0.996–1.001 0.260
Hemoglobin A1c, % 0.009 0.001–999.9 0.846
Cr before initiation of HD, mg/dL 0.964 0.894–1.041 0.350
BUN before initiation of HD, mg/dL 1.001 0.993–1.009 0.795
Standard Kt/Vurea 0.924 0.409–2.088 0.850
Uric acid, mg/dL 0.972 0.822–1.148 0.735
Total bilirubin, mg/dL 0.935 0.373–2.343 0.886
Alkaline phosphatase, IU/L 1.000 0.998–1.002 0.981
AST, IU/L 1.009 0.986–1.033 0.458
ALT, IU/L 1.006 0.992–1.021 0.414
γ-Glutamyl transferase, IU/L 1.000 0.997–1.002 0.707
Lactate dehydrogenase, IU/L 1.005 0.998–1.011 0.170
Triglyceride, mg/dL 0.999 0.998–1.001 0.456
HDL-cholesterol, mg/dL 1.003 0.986–1.020 0.708
LDL-cholesterol, mg/dL 0.994 0.986–1.002 0.133
C-reactive protein, mg/dL 0.933 0.886–0.981 0.007
ESR, mm/h 1.001 0.977–1.026 0.925
Intact PTH, pg/mL 1.000 0.999–1.001 0.347
25-hydroxy vitamin D, ng/mL 0.997 0.988–1.006 0.522
β2-microglobulin, mg/L 0.997 0.971–1.021 0.718

ChAdOx1 = ChAdOx1 nCoV-19 adenovirus-based vector vaccine, HR = hazard ratio, CI = confidence interval, SBP = systolic blood pressure, DBP = diastolic blood pressure, HD = hemodialysis, ARB = angiotensin II receptor blocker, CCB = calcium channel blocker, DPP4 = dipeptidyl peptidase-4, ESA = erythropoiesis-stimulating agent, Cr = creatinine, BUN = blood urea nitrogen, AST = aspartate aminotransferase, ALT = alanine aminotransferase, HDL = high-density lipoprotein, LDL = low-density lipoprotein, CRP = C-reactive protein, ESR = erythrocyte sedimentation rate, PTH = parathyroid hormone.