TABLE 7.
MDL competitive binding inhibition by other non-colchicine structure drugs.
| # | Drug | BTb % | BTb Kd (app), µM | CeTb % | CeTb Kd (app), µM |
|---|---|---|---|---|---|
| 25 | Tubulazole C | 31 | 10 | 10 | 153 |
| 26 | Tubulazole T | <1 | nd | 12 | 124 |
| 27 | Indanocine | 57 | 3.4 | 50 | 16 |
| 28 | T113242 | 44 | 5.8 | 2 | 872 |
| 29 | T138067 (Batabulin) | 36 | 8.0 | 4 | 415 |
| 30 | ABT-751 | 44 | 5.8 | 12 | 124 |
| 31 | TN16 | 74 | 1.5 | 34 | 32 |
| 32 | Tivantinib | 48 | 4.9 | 24 | 53 |
| 33 | Plinabulin | <1 | nd | <1 | nd |
| 34 | Lexibulin | 80 | 1.1 | 6 | 268 |
| 35 | Curvulin | 3 | 152 | 2 | 872 |
| 36 | Indibulin (D248510) | 7 | 61 | 10 | 153 |
| 37 | Curvularin | <1 | nd | <1 | nd |
| 38 | Dehydrocurvularin | 2 | 234 | 1 | 1865 |
| 39 | Tryprostatin | <1 | nd | <1 | nd |
| 40 | 2-methoxyestradiol (2-ME) | 12 | 33 | 1 | 1865 |
| 41 | Berberine | 4 | 111 | 2 | 872 |
| 42 | D-64131 | 90 | 0.5 | 73 | 6.2 |
| 43 | Ferulenol | 10 | 41 | 2 | 872 |
nd, not determined.