Table 1.
Association of lipids, lipoproteins, apolipoproteins, and their ratios with ischemic stroke, by etiology
| Risk factor | Large vessel |
Small vessel |
Cardioembolism |
Undetermined |
||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | PAR (95% CI) | OR (95% CI) | PAR (95% CI) | OR (95% CI) | PAR (95% CI) | OR (95% CI) | PAR (95% CI) | |
| LDL T2 vs. T1 | 1.02 (0.83–1.25) | 5.9 (0.9–31.7) | 0.88 (0.76–1.02) | - | 1.14 (0.80–1.62) | 9.2 (1.4–42.6) | 1.07 (0.89–1.28) | 10.6 (4.1–24.5) |
| LDL T3 vs. T1 | 1.18 (0.96–1.47) | 0.89 (0.77–1.04) | 1.25 (0.84–1.85) | 1.32 (1.09–1.59) | ||||
| HDL T2 vs. T1 | 0.80 (0.66–0.97) | 35.7 (27.1–45.3) | 0.71 (0.61–0.82) | 31.0 (24.6–38.2) | 0.74 (0.52–1.05) | 13.1 (2.6–45.9) | 0.89 (0.74–1.07) | 23.1 (15.3–33.4) |
| HDL T3 vs. T1 | 0.50 (0.40–0.62) | 0.51 (0.44–0.60) | 0.70 (0.47–1.05) | 0.65 (0.53–0.79) | ||||
| LDL/HDL T2 vs. T1 | 1.27 (1.03–1.58) | 28.7 (20.3–39.0) | 1.29 (1.10–1.51) | 23.7 (17.0–31.9) | 1.28 (0.90–1.84) | 18.1 (7.1–38.7) | 1.14 (0.94–1.38) | 20.4 (12.7–31.1) |
| LDL/HDL T3 vs. T1 | 2.00 (1.61–2.50) | 1.61 (1.38–1.88) | 1.55 (1.02–2.34) | 1.68 (1.39–2.03) | ||||
| ApoB T2 vs. T1 | 1.03 (0.84–1.26) | 13.4 (4.3–34.8) | 1.06 (0.92–1.22) | 5.8 (1.4–20.5) | 0.88 (0.61–1.27) | - | 1.04 (0.87–1.25) | 7.7 (1.3–35.3) |
| ApoB T3 vs. T1 | 1.44 (1.18–1.77) | 1.14 (0.98–1.32) | 1.05 (0.70–1.57) | 1.19 (0.99–1.44) | ||||
| ApoA1 T2 vs. T1 | 0.52 (0.42–0.63) | 49.5 (39.0–59.9) | 0.57 (0.49–0.66) | 40.9 (35.2–46.8) | 0.74 (0.52–1.07) | 43.2 (28.9–58.8) | 0.59 (0.49–0.71) | 36.8 (29.4–45.0) |
| ApoA1 T3 vs. T1 | 0.31 (0.24–0.39) | 0.36 (0.31–0.43) | 0.43 (0.25–0.74) | 0.41 (0.33–0.51) | ||||
| ApoB/A1 T2 vs. T1 | 1.72 (1.37–2.16) | 47.6 (40.1–55.2) | 1.32 (1.14–1.53) | 27.6 (21.6–34.6) | 1.34 (0.90–1.98) | 32.0 (17.5–51.0) | 1.26 (1.04–1.52) | 28.6 (20.9–37.8) |
| ApoB/A1 T3 vs. T1 | 3.10 (2.47–3.89) | 1.91 (1.63–2.23) | 1.99 (1.32–2.99) | 2.02 (1.65–2.46) | ||||
All models adjusted for age, sex, geographic region, and potential confounders (smoking, hypertension, diabetes mellitus, physical activity, diet, psychosocial factors, waist-to-hip ratio, alcohol intake, and cardiac causes of stroke). For LDL and small vessel ischemic stroke, apoB and cardioembolism, PAR was negative and not reported.
OR, odds ratio; CI, confidence interval; PAR, population attributable risk; LDL, low-density lipoprotein; HDL, high-density lipoprotein; Apo, apolipoprotein.