Table 2.
Association of lipoprotein and apolipoprotein ratios with ischemic stroke, by ethnicity
| Risk factor | Prevalence |
Ischemic stroke |
||
|---|---|---|---|---|
| No. of controls (%) | No. of ischemic (%) | OR (95% CI) | PAR (95% CI) | |
| European | ||||
| ApoB/A1 T2 vs. T1 | 924 (36.9) | 810 (32.6) | 1.33 (1.09–1.60) | 32.9 (25.0–41.9) |
| ApoB/A1 T3 vs. T1 | 796 (31.8) | 1,151 (46.4) | 2.15 (1.76–2.63) | |
| LDL/HDL T2 vs. T1 | 811 (32.9) | 744 (30.6) | 1.28 (1.07–1.53) | 23.0 (16.7–30.8) |
| LDL/HDL T3 vs. T1 | 543 (22.0) | 793 (32.6) | 1.99 (1.63–2.43) | |
| Chinese | ||||
| ApoB/A1 T2 vs. T1 | 990 (34.6) | 1,047 (36.7) | 1.45 (1.25–1.69) | 26.1 (20.7–32.4) |
| ApoB/A1 T3 vs. T1 | 522 (18.2) | 824 (28.9) | 2.04 (1.71–244) | |
| LDL/HDL T2 vs. T1 | 1,050 (36.5) | 931 (32.6) | 1.09 (0.91–1.30) | 15.7 (8.2–27.9) |
| LDL/HDL T3 vs. T1 | 1,041 (36.2) | 1,264 (44.2) | 1.41 (1.19–1.68) | |
| South Asian | ||||
| ApoB/A1 T2 vs. T1 | 538 (31.4) | 441 (27.3) | 1.27 (0.98–1.64) | 33.7 (23.4–45.9) |
| ApoB/A1 T3 vs. T1 | 763 (44.6) | 897 (55.6) | 2.02 (1.59–2.58) | |
| LDL/HDL T2 vs. T1 | 450 (28.0) | 421 (27.6) | 1.35 (1.06–1.74) | 27.5 (17.9–39.9) |
| LDL/HDL T3 vs. T1 | 666 (41.4) | 749 (49.1) | 1.71 (1.35–2.16) | |
| Other Asian | ||||
| ApoB/A1 T2 vs. T1 | 145 (35.5) | 96 (23.2) | 1.54 (0.82–2.90) | 55.4 (34.7–74.4) |
| ApoB/A1 T3 vs. T1 | 167 (40.8) | 274 (66.2) | 3.51 (1.96–6.28) | |
| LDL/HDL T2 vs. T1 | 140 (36.0) | 118 (28.7) | 2.10 (1.14–3.87) | 52.3 (32.8–71.1) |
| LDL/HDL T3 vs. T1 | 139 (35.7) | 229 (55.7) | 3.08 (1.71–5.54) | |
| Latin American | ||||
| ApoB/A1 T2 vs. T1 | 315 (30.7) | 267 (27.8) | 1.48 (1.06–2.07) | 33.3 (19.6–50.4) |
| ApoB/A1 T3 vs. T1 | 474 (46.1) | 542 (56.5) | 1.73 (1.27–2.37) | |
| LDL/HDL T2 vs. T1 | 354 (35.8) | 330 (35.0) | 1.24 (0.93–1.66) | 16.1 (6.3–35.5) |
| LDL/HDL T3 vs. T1 | 299 (30.2) | 333 (35.3) | 1.35 (1.00–1.83) | |
| African | ||||
| ApoB/A1 T2 vs. T1 | 129 (30.0) | 97 (23.2) | 1.40 (0.84–2.32) | 47.5 (30.4–65.2) |
| ApoB/Apo-A1 T3 vs. T1 | 179 (41.6) | 263 (62.9) | 2.88 (1.76–4.69) | |
| LDL/HDL T2 vs. T1 | 138 (32.2) | 137 (32.4) | 1.55 (1.00–2.40) | 32.6 (18.0–51.5) |
| LDL/HDL T3 vs. T1 | 130 (30.4) | 189 (44.7) | 1.89 (1.21–2.93) | |
All models adjusted for age, sex, geographic region, and potential confounders (smoking, diabetes mellitus, physical activity, diet, psychosocial factors, waistto-hip ratio, and alcohol intake).
OR, odds ratio; CI, confidence interval; PAR, population attributable risk; Apo, apolipoprotein; LDL, low-density lipoprotein; HDL, high-density lipoprotein.