Table 1.
Variables selected in the multivariable cox regression model for prediction of all-cause mortality
| Variable | HR (95% CI) | P |
|---|---|---|
| sNfL (pg/mL) per 1-SD increase*,† | 1.233 (1.084–1.423) | 0.003 |
| Demographics | ||
| Age squared per 1-SD increase | 2.031 (1.632–2.531) | <0.001 |
| Sex | NS | NS |
| Cognition | ||
| Cognitive index | 0.704 (0.581–0.853) | <0.001 |
| Vascular risk factors | ||
| Hypertension | NS | NS |
| Diabetes | 1.263 (0.870–1.832) | 0.231 |
| Smoking | 1.630 (1.133–2.371) | 0.012 |
| Comorbidity | ||
| Cardiovascular events | 1.192 (0.854–1.671) | 0.314 |
| MRI characteristics | ||
| WMH (mL) per 1-SD increase* | NS | NS |
| GMV (mL) per 1-SD increase | 0.871 (0.720–1.064) | 0.180 |
| WMV (mL) per 1-SD increase | 0.840 (0.702–0.991) | 0.041 |
| MD white matter 10-3 mm2/sec per 1-SD increase‡ | 1.052 (0.943–1.170) | 0.382 |
| Presence of microbleeds | NS | NS |
| Presence of lacunes | 1.243 (0.881–1.752) | 0.224 |
Variables selected after applying lasso regression.
HR, hazard ratio; CI, confidence interval; sNfL, serum neurofilament light chain; SD, standard deviation; NS, not selected (by lasso regression); MRI, magnetic resonance imaging; WMH, white matter hyperintensities; GMV, grey matter volume; WMV, white matter volume; MD, mean diffusivity.
*
Log-transformed;
†
Age-normalized;
‡
Three patients excluded because of insufficient scan quality.