Table 5.
Studies evaluating significance of collateral on outcomes
| Author (year) (study period) | Design | No. of patients | Classification of collaterals | Main study results |
|---|---|---|---|---|
| Singer et al. (2015) [41] (2011–2013) | Multicenter ENDOSTROKE registry | 148 BAO EVT | ASITN/SIR grade | Collaterals associated with good clinical outcome (aOR, 2.12; P=0.023) and recanalization (aOR, 3.087; P=0.002) |
| TFCA | ||||
| van Houwelingen et al. (2016) [65] (2006–2015) | Single center retrospective | 38 BAO EVT | Composite collateral score | No association between collateral score and outcomes |
| van der Hoeven et al. (2016) [61] (2002–2007) | BASICS registry | 149 BAO | PC-CS | Lower risk of poor outcome for good PC-CS (6–10) than with poor PC-CS (0–3) (RR, 0.74; 95% CI, 0.58–0.96) |
| Alemseged et al. (2017) [62] (2005–2016) | Prospective multicenter 2005–2016 | 124 BAO | BATMAN | BATMAN score of <7 associated with poor outcomes (aOR, 5.5; 95% CI, 1.4–21) |
| Luo et al. (2018) [47] (2012–2016) | Single center | 69 BAO EVT | ASITN/SIR grade | ≥2 points associated with mortality (aOR, 0.210; 95% CI, 0.059–0.752) |
| Alemseged et al. (2019) [64] (2002–2017) | Multicenter BATMAN & BASICS registry | 172 BAO EVT | BATMAN | Early (time-to-treatment ≤6 hours) but not late revascularization associated with improved outcome in patients with unfavorable collaterals |
| Lee et al. (2020) [52] (2011–2016) | Multiceneter ASIAN KR registry | VBAO EVT | PC-CS, BATMAN | No association between collaterals and outcomes |
| Derivation: 71 | ||||
| Validation: 32 | ||||
| Kwak et al. (2020) [63] (2012–2019) | Single center retrospective | 81 BAO EVT | BATMAN, PC-CS | PC-CS ≥6 associated with good functional outcome (aOR, 3.79; 95% CI, 1.05–13.66) |
| Yang et al. (2018) [66] (2012–2016) | Single center prospective | 63 BAO EVT | DSA | BATMAN score >3 associated with good outcome (aOR, 5.214; 95% CI, 1.47–18.483) |
| BATMAN |
ENDOSTROKE, Endovascular Stroke Treatment; BAO, basilar artery occlusion; EVT, endovascular treatment; ASITN/SIR, The American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology; TFCA, transfemoral cerebral angiography; aOR, adjusted odds ratio; BASICS, Basilar Artery International Cooperation Study; PC-CS, posterior circulation collateral score; RR, risk ratio; CI, confidence interval; BATMAN, Basilar Artery on Computer Tomography Angiography; ASIAN KR, Acute Stroke due to Intracranial Atherosclerotic occlusion and Neurointervention Korean Retrospective; VBAO, vertebrobasilar artery; DSA, digital subtraction angiography.